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Controlled-release hydromorphone and risk of infection in adults: a systematic review
BackgroundPreliminary evidence suggests that people who inject drugs (PWID) may be at an increased risk of develo** infective endocarditis (IE),...
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Sonographically controlled minimally-invasive A1 pulley release using a new guide instrument – a case series of 106 procedures in 64 patients
BackgroundWith percutaneous and minimally-invasive pulley release becoming more popular, safety and reliability of such minimally-invasive procedures...
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Real-World Safety and Effectiveness of Controlled-Release Cilostazol in Patients with Symptomatic Peripheral Artery Disease
BackgroundCilostazol is the only first-line medication for treating intermittent claudication, and the controlled-release (CR) formulation is...
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Comparing the effectiveness of extracorporeal shockwave therapy and myofascial release therapy in chronic pelvic pain syndrome: study protocol for a randomized controlled trial
BackgroundChronic prostatitis/chronic pelvic pain syndrome is a highly prevalent syndrome. Previous studies showed that extracorporeal shockwave...
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Protocol for Endoscopic Versus Open Cubital tunnel release (EVOCU): an open randomized controlled trial
BackgroundCubital tunnel syndrome is the second most common entrapment neuropathy of the upper extremity. Surgical decompression of the ulnar nerve...
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RELEASE (REdressing Long-tErm Antidepressant uSE): protocol for a 3-arm pragmatic cluster randomised controlled trial effectiveness-implementation hybrid type-1 in general practice
BackgroundMany people experience withdrawal symptoms when they attempt to stop antidepressants. Withdrawal symptoms are readily misconstrued for...
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Pharmacodynamic and pharmacokinetic properties of the combined preparation of levothyroxine plus sustained- release liothyronine; a randomized controlled clinical trial
BackgroundUnderstanding pharmacokinetics (PK) and pharmacodynamics (PD) of the sustained-release liothyronine (SR-T3) is of paramount importance to...
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Foley catheter and controlled release dinoprostone versus foley catheter labor induction in nulliparas: a randomized trial
PurposeTo evaluate Foley catheter and controlled release dinoprostone insert compared to foley catheter alone on induction to delivery interval and...
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Effect of simultaneous application of positional release technique and Maitland mobilization technique on sciatica: a randomized controlled trial
BackgroundLow back pain (LBP) associated with sciatica is considered the primary cause of seeking medical and physical therapy advice. Treating...
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Microsponges: a promising frontier for prolonged release-current perspectives and patents
BackgroundMicrosponges are one of the advanced drug delivery systems that facilitates precise and controlled release of active ingredients that are...
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The recent insight in the release of anticancer drug loaded into PLGA microspheres
Cancer is a series of diseases leading to a high rate of death worldwide. Microspheres display specific characteristics that make them appropriate...
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Efficacy and Safety of Tramadol Hydrochloride Twice-Daily Sustained-Release Bilayer Tablets with an Immediate-Release Component for Chronic Pain Associated with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study
Background and ObjectivesKnee osteoarthritis pain is a chronic form of pain for which conventional non-steroidal anti-inflammatory drugs may provide...
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Long-term clinical benefits of delayed-release cysteamine bitartrate capsules in patients with nephropathic cystinosis (response to “A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis”)
The aim of this letter to the editor is to summarize the results from three clinical trial programs evaluating delayed-release cysteamine bitartrate...
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Sustained-release drug delivery systems
The design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to...
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Gastrocnemius Release in the Treatment of Achilles Tendinopathy: A Systematic Review
BackgroundThe aim of this study is to evaluate the use of isolated gastrocnemius release in the treatment of Achilles tendinopathy. The primary...
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Examining Pre-Release Interventions on HIV Outcomes 12 Months After Release from Louisiana State Corrections
Louisiana has the highest proportion of people living with HIV (PLWH) in state prison custody. Linkage to care programs minimize odds of HIV care...
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Posterior component separation with transversus abdominis muscle release versus mesh-only repair in the treatment of complex ventral-wall hernia: a randomized controlled trial
BackgroundComplex ventral hernias (VHs) represent a real challenge to both general and plastic surgeons. This study aims to compare Sublay Mesh-Only...
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Early pathophysiology-driven airway pressure release ventilation versus low tidal volume ventilation strategy for patients with moderate-severe ARDS: study protocol for a randomized, multicenter, controlled trial
BackgroundConventional Mechanical ventilation modes used for individuals suffering from acute respiratory distress syndrome have the potential to...
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Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach
BackgroundChronic conditions such as nocturnal asthma, cardiac disorder, diabetes mellitus, joint pain and inflammation, and hypercholesterolemia...
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Sustained Release Therapies with the Prostaglandin Analogues Intracameral Implants
The travoprost intracameral implant was recently approved by the US Food and Drug Administration for sustained release medical treatment of...
