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A decellularized flowable placental connective tissue matrix supports cellular functions of human tenocytes in vitro
PurposeInjectable connective tissue matrices (CTMs) may promote tendon healing, given their minimally invasive properties, structural and biochemical...
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Root coverage surgeries using modified tunneling technique of xenogenic collagen matrix versus autologous connective tissue graft as a treatment of Miller class II gingival recession (RCT study)
BackgroundRecently, there is increased demand for periodontal plastic surgery and development of new surgical approaches for aesthetic purposes....
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Magnesium deficiency and its interaction with the musculoskeletal system, exercise, and connective tissue: an evidence synthesis
BackgroundRegular physical exercise is an essential part of a healthy lifestyle, maintaining and strengthening public health. Recently, a steady...
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Unraveling the genetic collagen connection: clinical and therapeutic insights on genetic connective tissue disorders
Hereditary connective tissue disorders include more than 200 conditions affecting different organs and tissues, compromising the biological role of...
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Clinical characteristics of patients with connective tissue disease–related interstitial lung disease: a retrospective analysis
IntroductionInterstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and...
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Treatment of calcinosis cutis associated with autoimmune connective tissue diseases
Calcinosis cutis is a condition that is commonly associated with autoimmune connective tissue diseases. It is characterized by the deposition of...
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Outcomes of complex abdominal wall reconstruction in patients with connective tissue disorders: a single center experience
IntroductionIndividuals diagnosed with connective tissue disorders (CTD) are known to be predisposed to incisional hernia formation. However, there...
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Connective tissue nevus misdiagnosed as juvenile localized scleroderma
BackgroundConnective tissue nevi (CTN) are congenital hamartomas caused by excessive proliferation of dermis components. In children, CTN can mimic...
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Characterization of cervical tissue using Mueller matrix polarimetry
The cervix is composed of layers of squamous epithelium and connective tissue. The main component of the cervical connective tissue is collagen,...
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Back to the future: targeting the extracellular matrix to treat systemic sclerosis
Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is composed principally of highly crosslinked type I...
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Connective Tissue Growth Factor Single Nucleotide Polymorphisms in (Familial) Pulmonary Fibrosis and Connective Tissue Disease Associated Interstitial Lung Disease
PurposeConnective tissue growth factor (CTGF) is an important mediator in fibrotic disease. Single nucleotide polymorphisms (SNPs) in CTGF have been...
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Clinical and radiological features of lung disorders related to connective-tissue diseases: a pictorial essay
Connective tissue diseases (CTDs) include a spectrum of disorders that affect the connective tissue of the human body; they include autoimmune...
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Degenerative tendon matrix induces tenogenic differentiation of mesenchymal stem cells
PurposeMesenchymal stem cells (MSCs) react dynamically with the surrounding microenvironment to promote tissue-specific differentiation and hence...
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Application of color doppler ultrasound and US shear wave elastography with connective tissue growth factor in the risk assessment of papillary thyroid carcinoma
BackgroundThis study aims to investigate the role of shear wave elastography (SWE) and connective tissue growth factor (CTGF) in the assessment of...
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Plasma LTBP2 as a potential biomarker in differential diagnosis of connective tissue disease-associated interstitial lung disease and idiopathic pulmonary fibrosis: a pilot study
Few biomarkers distinguish connective tissue disease-associated interstitial lung disease (CTD-ILD) from idiopathic pulmonary fibrosis (IPF). Latent...
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Serum MMP-9, SP-D, and VEGF levels reflect the severity of connective tissue disease-associated interstitial lung diseases
BackgroundInterstitial lung disease (ILD) is a common pulmonary complication of connective tissue disease (CTD). This study aims to evaluate the...
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Autologous hematopoietic stem cell transplantation promotes connective tissue remodeling in systemic sclerosis patients
BackgroundAutologous hematopoietic stem cell transplantation (AHSCT) treats patients with severe and progressive systemic sclerosis (SSc). However,...
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A systematic review of the incidence, management and prognosis of new-onset autoimmune connective tissue diseases after COVID-19
A literature review on new-onset autoimmune connective tissue diseases (ACTDs) following COVID-19 is lacking. We evaluated potential associations...
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Extracellular matrix stiffness and tumor-associated macrophage polarization: new fields affecting immune exclusion
In the malignant progression of tumors, there is deposition and cross-linking of collagen, as well as an increase in hyaluronic acid content, which...
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Osteogenesis imperfecta and rheumatoid arthritis: connective issues
The coexistence of osteogenesis imperfecta and inflammatory arthritis has been very rarely described. Nevertheless, systemic inflammation has been...