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Discovery of small molecule degraders for modulating cell cycle
The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is...
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Targeting cardiomyocyte cell cycle regulation in heart failure
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult...
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USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation
The reversible post-translational modifications of protein ubiquitination and deubiquitination play a crucial regulatory role in cellular...
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Rhein suppresses esophageal cancer development by regulating cell cycle through DNMT3B gene
The mechanism by which DNMT3B facilitates esophageal cancer (ESCA) progression is currently unknown, despite its association with adverse prognoses...
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Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells
ObjectiveTo determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer (CRC) through...
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Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability
The deubiquitinase OTUB1, implicated as a potential oncogene in various tumors, lacks clarity in its regulatory mechanism in tumor progression. Our...
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Intrinsic Resistance to Osimertinib in EGFR Mutated NSCLC Cell Lines Induced by Alteration in Cell-Cycle Regulators
BackgroundCell-cycle regulators are mutated in approximately 40% of all cancer types and have already been linked to worse outcomes in non-small cell...
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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis
ObjectiveEndometrial carcinoma (EC) is a prevalent gynecological malignancy characterized by increasing incidence and mortality rates. This...
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Chidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway
ObjectiveThe initial therapeutic approach for diffuse large B-cell lymphoma (DLBCL) entails a rituximab, cyclophosphamide, doxorubicin, vincristine,...
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Late gestation fetal hypothyroidism alters cell cycle regulation across multiple organ systems
BackgroundHypothyroidism is a common endocrine disruption observed in utero that adversely affects fetal growth and maturation leading to long-term...
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Cuproptosis-related ceRNA axis triggers cell proliferation and cell cycle through CBX2 in lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) has high morbidity and mortality. Despite substantial advances in treatment, the prognosis of patients with LUAD...
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Lenvatinib inhibits intrahepatic cholangiocarcinoma via Gadd45a-mediated cell cycle arrest
PurposeTo evaluate the anticancer activities of lenvatinib in ICC and its possible molecular mechanisms.
MethodsPatients-derived xenograft (PDX)...
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Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells
Artesunate (ART), an effective antimalarial semisynthetic derivative of artemisinin, exhibits antitumour properties, but the mechanism(s) involved...
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Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium
The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation causes a syndromic form of autism spectrum disorder (ASD):...
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ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma
Lung adenocarcinoma is a malignant tumor with high morbidity and mortality. ZBTB16 plays a double role in various tumors; however, the potential...
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Deciphering Annona’s Anticancer Potential: Comparative Analysis of Crude Extract Versus Nanoformulation on SCC-25 Oral Cancer Cells Through cell Viability, Apoptosis, Cell Cycle, ROS, and MMP Analysis
IntroductionAnnona muricata contains acetogenins, which have shown promising anticancer activity against various cell lines. This study aims to...
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N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition
Multiple myeloma (MM) is the second most common hematological malignancy. N6-methyladenosine (m 6 A) is the most abundant RNA modification. YTH...
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Targeting EFNA1 suppresses tumor progression via the cMYC-modulated cell cycle and autophagy in esophageal squamous cell carcinoma
PurposeEsophageal squamous cell carcinoma (ESCC) remains one of the most common causes of cancer death due to the lack of effective therapeutic...
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KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia
ObjectiveTo identify key gene in childhood acute lymphoblastic leukemia (ALL) through weighted gene co-expression network analysis (WGCNA), and their...
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TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2–PI3K–AKT pathway activation
BackgroundTRAF-interacting protein (TRAIP) is a RING-type E3 ubiquitin ligase, which has been implicated in various cellular processes and...
