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1. Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia

   Background

   Rewarming from hypothermia is associated with severe complications, one of which is hypothermia-induced cardiac dysfunction. This condition...

   Anders Lund Selli, Adrina Kalasho Kuzmiszyn, ... Erik Sveberg Dietrichs in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

   Article Open access 15 December 2022
   

2. cGMP compliant one-step, one-pot automated [¹⁸F]FBnTP production for clinical imaging of mitochondrial activity

   Background

   4-[ ¹⁸ F]fluorobenzyl-triphenylphosphonium ([ ¹⁸ F]FBnTP) is a lipophilic cation PET tracer. The cellular uptake of [ ¹⁸ F]FBnTP is correlated...

   Mai Lin, Cong-Dat Pham, ... H. Charles Manning in EJNMMI Radiopharmacy and Chemistry

   Article Open access 27 June 2024
   

3. Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway

   Background

   Tracheal injury is a common clinical condition that still lacks an effective therapy at present. Stimulation of epithelial sodium channel...

   **aoyong **e, Tong Yu, ... Yong Cui in Respiratory Research

   Article Open access 04 December 2021
   

4. Therapeutic augmentation of NO-sGC-cGMP signalling: lessons learned from pulmonary arterial hypertension and heart failure

   The nitric oxide (NO)–guanylate cyclase (GC)–cyclic guanosine monophosphate (cGMP) pathway plays an important role in cardiovascular, pulmonary and...

   Filippos Triposkiadis, Andrew Xanthopoulos, ... Randall C. Starling in Heart Failure Reviews

   Article 18 April 2022
   

5. Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [⁶⁸Ga]Ga-ABY-025 tracer

   Background

   The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either...

   Emma Jussing, Mélodie Ferrat, ... Thuy A. Tran in EJNMMI Radiopharmacy and Chemistry

   Article Open access 22 November 2023
   

6. The sGC-cGMP Signaling Pathway as a Potential Therapeutic Target in Doxorubicin-Induced Heart Failure: A Narrative Review

   The anti-cancer agent doxorubicin (DOX) has high cardiotoxicity that is linked to DOX-mediated increase in oxidative stress, mitochondrial iron...

   Haneul Cho, **ao-**ao Zhao, ... Weon Kim in American Journal of Cardiovascular Drugs

   Article 21 June 2021
   

7. Avanafil as a Novel Therapeutic Agent Against LPS-Induced Acute Lung Injury via Increasing CGMP to Downregulate the TLR4-NF-κB-NLRP3 Inflammasome Signaling Pathway

   Aim

   We demonstrate the effect of PDE5 inhibitors in cases of acute lung injury via the relationship between cGMP/NO and the TLR4-NF-κB-NLRP3 pathway.

   ...

   Pelin Aydin, Zeynep Berna Aksakalli Magden, ... Elif Cadirci in Lung

   Article 30 August 2022
   

8. Activation of the cGMP/PKG/ERK signaling pathway associated with PDE5Is inhibits fibroblast activation by downregulating autophagy in early progressive benign prostatic hyperplasia

   Purpose

   Benign prostatic hyperplasia (BPH) is one of the most prevalent diseases affecting aging males. However, approximately, 8% of the BPH patients...

   Song **, Zhanliang Liu, ... Yinong Niu in World Journal of Urology

   Article 18 May 2024
   

9. Abnormal cGMP-dependent protein kinase I-mediated decidualization in preeclampsia

   Defective decidual function contributes to the pathogenesis of preeclampsia. However, the precise mechanism of defective decidua during preeclampsia...

   **gsi Chen, Wenlu Ren, ... Lili Du in Hypertension Research

   Article 23 October 2020
   

10. Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling

    Introduction

    Natriuretic peptide receptor-A (NPR-A) signaling system is considered as an intrinsic productive mechanism of the heart that opposes...

    Gopinath Nagaraj, Elangovan Vellaichamy in Endocrine

    Article 07 May 2024
    

11. Banxia **exin Decoction (半夏泻心汤) Treats Diabetic Gastroparesis through PLC-IP₃-Ca²⁺/NO-cGMP-PKG Signal Pathway

    Objective

    To test the effect of Banxia **exin Decoction (半夏泻心汤, BXD) on the contraction and relaxation of gastric smooth muscle (SM) in diabetic...

    Bin Wang, Ke-wu Zeng, ... Zhen Liu in Chinese Journal of Integrative Medicine

    Article 16 May 2020

12. The potential involvement of MRP5 pump in urethral dysfunction in streptozotocin-induced diabetic rats

    Purpose

    To examine the effects of i.v. administration of MK-571, a MRP4/5 pump inhibitor, on urethral function in the urethane-anesthetized rat, and...

    Rong Lv, Jianwen Huang, ... Nailong Cao in International Urology and Nephrology

    Article 03 November 2022
    

13. Perioperative redox changes in patients undergoing hepato-pancreatico-biliary cancer surgery

    Background

    Tissue injury induces inflammation and the surgical stress response, which are thought to be central to the orchestration of recovery or...

    Jia L. Stevens, Helen T. McKenna, ... Daniel S. Martin in Perioperative Medicine

    Article Open access 10 July 2023
    

14. Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats

    Inadequate release of nitric oxide (NO) by the penile tissue impacts negatively on penile erection causing erectile dysfunction (ED). Fadogia agrestis ...

    Olalekan Bukunmi Ogunro, Musa Toyin Yakubu in Reproductive Sciences

    Article 15 August 2022
    

15. Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure

    Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of cardiac function by degrading cAMP and cGMP. In cardiomyocytes,...

    Rima Kamel, Jérôme Leroy, ... Rodolphe Fischmeister in Nature Reviews Cardiology

    Article 01 September 2022
    

16. Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors

    Background

    As known, inhibition of phosphodiesterase 5 (PDE5) has the therapeutic effect on male erectile dysfunction (ED), and the processed folium...

    Juntao Li, Yue Wu, ... **angwei Zheng in Chinese Medicine

    Article Open access 31 December 2022
    

17. Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes

    In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment. An alternative to commonly used ovarian...

    Patrycja Strączyńska, Krzysztof Papis, ... Anna Bednarska-Czerwińska in Reproductive Biology and Endocrinology

    Article Open access 24 February 2022
    

18. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K⁺ channel tracer [¹¹C]3MeO4AP

    Background

    4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been...

    Yu-Peng Zhou, Moses Q. Wilks, ... Pedro Brugarolas in EJNMMI Research

    Article Open access 29 April 2024
    

19. Azelnidipine protects HL-1 cardiomyocytes from hypoxia/reoxygenation injury by enhancement of NO production independently of effects on gene expression

    It remains to be elucidated whether Ca ²⁺ antagonists induce pharmacological preconditioning to protect the heart against ischemia/reperfusion injury....

    Hiroyuki Minato, Ryo Endo, ... Akihiro Otsuki in Heart and Vessels

    Article 26 May 2024
    

20. Inhibitory Effect of **kui Shenqi Pills on Glucocorticoid-Enhanced Axial Length Elongation in Experimentally Myopic Guinea Pigs

    Objective

    To explore the underlying mechanism of inhibition by **kui Shenqi Pills (JKSQP) on glucocorticoid-enhanced axial length elongation in...

    Qian Jiang, Wen-jun Jiang, ... Hong-sheng Bi in Chinese Journal of Integrative Medicine

    Article 12 May 2023