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High-intensity interval training protects the heart against acute myocardial infarction through SDF-1a, CXCR4 receptors, and c-kit levels
One of the best and most effective applied and tolerable approaches for cardioprotection is the regular exercise . In the situation of exercise...
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GnRH antagonist weakens endometrial stromal cells growth ability by decreasing c-kit receptor expression
BackgroundSeveral surveys have reported that patients treated with gonadotropin-releasing hormone antagonist (GnRH-ant) protocol showed a...
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Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor
BackgroundGastrointestinal stromal tumor (GIST) is a rare type of cancer that occurs in the gastrointestinal tract. The majority of GIST cases carry...
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miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit
BackgroundExcessive autophagy and apoptosis of the interstitial cells of Cajal (ICC) have been identified in gastrointestinal (GI) motility disorders...
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A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth
PurposeImatinib, a small-molecule tyrosine kinase inhibitor, has shown good clinical activity by inhibiting adenosine triphosphate (ATP) binding to...
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A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis
BackgroundCanine malignant melanoma is highly aggressive and generally chemoresistant. Toceranib is a kinase inhibitor drug that inhibits several...
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SCF Improves In Vitro Differentiation of SSCs Through Transcriptionally Up-regulating PRTM1, STRA8, c-KIT, PIWIL2, and OCT4 Genes
Several lines of evidence strongly suggest that retinoic acid (RA) and stem cell factor (SCF)/c-Kit signal transduction pathways are involved in the...
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Germ cells positive for PLAP and c-Kit in 11–16 year old normal boys with ongoing spermatogenesis
IntroductionPositive staining of testicular germ cells for PLAP and c-Kit beyond infancy may be associated with the presence of GCNIS (Germ Cell...
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Apatinib exhibits synergistic effect with pyrotinib and reverses acquired pyrotinib resistance in HER2-positive gastric cancer via stem cell factor/c-kit signaling and its downstream pathways
BackgroundRecently, progress has been made in the development of targeted therapies for human epidermal growth factor receptor 2 (HER2)-positive...
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C-kit signaling promotes human pre-implantation 3PN embryonic development and blastocyst formation
BackgroundAlthough in vitro culture system has been optimized in the past few decades, the problem of few or no high quality embryos has been still...
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The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats
BackgroundExercise training is known as a practical way to increase cardioprotection against stress, and it seems that stem cell recruitment is one...
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Correction to: SCF Improves In Vitro Differentiation of SSCs Through Transcriptionally Up-regulating PRTM1, STRA8, c-KIT, PIWIL2, and OCT4 Genes
A Correction to this paper has been published: https://doi.org/10.1007/s43032-021-00498-2
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Development of multiple features of antigen-induced asthma pathology in a new strain of mast cell deficient BALB/c-KitW-sh/W-sh mice
Mast cell-deficient mice are widely used to identify and quantify contributions of mast cells to diverse biological responses in vivo, including...
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Long-term c-Kit overexpression in beta cells compromises their function in ageing mice
Aims/hypothesisc-Kit signalling regulates intracellular pathways that enhance beta cell proliferation, insulin secretion and islet vascularisation in...
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The evaluation results of proposed antigen rapid diagnostic tests for COVID-19: some possible factors might influence
PurposeIn addition to existing gold standard qRT-PCR methods, there is a need to develop reliable rapid tests for infection control with early...
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Anaplastic lymphoma kinase expression in PDGFRA-mutated gastrointestinal stromal tumors probably correlates with poor prognosis
BackgroundAnaplastic lymphoma kinase (ALK) overexpression and gene alterations have been detected in several mesenchymal tumors, with significant...
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Interstitial cells of Cajal: clinical relevance in pediatric gastrointestinal motility disorders
Interstitial cells of Cajal (ICCs) are pacemaker cells of gastrointestinal motility that generate and transmit electrical slow waves to smooth muscle...
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An all-37 °C thawing method improves the clinical outcomes of vitrified frozen-thawed embryo transfer: a retrospective study using a case–control matching analysis
PurposeThe purpose of this study is to assess the impact of different temperatures and incubation times on the clinical outcomes of FET cycles during...
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we...
