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MiR-34c-5p Inhibition Affects Bax/Bcl2 Expression and Reverses Bortezomib Resistance in Multiple Myeloma Cells
Develo** resistance to anticancer drugs complicates the clinical treatment of multiple myeloma patients. Previous studies revealed a link between...
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Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis
Botulinum toxin type A (BTXA) has the potential to treat androgenetic alopecia (AGA); however, its impact on the apoptosis of dermal papillary cells...
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Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress–Induced-Sertoli Cells Apoptosis
The problem of male infertility is a global health crisis and poses a serious threat to the well-being of families. Under heat stress (HS), the...
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Shenqi Fuzheng injection hinders non-small cell lung cancer cell growth by regulating the Bax/Bcl-2 signaling pathway
IntroductionLung cancer (LC) is the most common solid tumor and is currently considered the primary cause of cancer-related deaths worldwide. In...
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Dermaseptin B2 bioactive gene’s potential for anticancer and anti-proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway
Dermaseptin B2 (DrsB2) is an antimicrobial peptide with anticancer and angiostatic properties. We aimed to assess the in vitro inhibitory effect of...
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The Comparative Effect of Plasma Exosomes of Young and Old People on the Expression of BCL-2 and BAX Genes in Hematopoietic Stem Cells
Apoptosis may disrupt differentiation of hematopoietic stem cells (HSCs), which can affect aging. Thus, the main goal of this study was to compare...
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Beneficial effects of time and energy restriction diets on the development of experimental acute kidney injury in Rat: Bax/Bcl-2 and histopathological evaluation
People’s lifestyles and, especially, their eating habits affect their health and the functioning of the organs in their bodies, including the...
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Dietary flavonoid carvacrol triggers the apoptosis of human breast cancer MCF-7 cells via the p53/Bax/Bcl-2 axis
Recently, numerous studies have shown that natural compounds such as carvacrol can be used as therapeutic agents for medicinal purposes. Although...
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Effect of Dioscorea extract on Bax and Bcl-2 gene expression in MCF-7 and HFF cell lines
BackgroundIn cancer cells, the balance between proliferation and apoptosis is disturbed. There is a direct relationship between gene expression and...
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Cardiac remodeling, apoptosis-related process (Bax, Bcl-2), and their ratio (Bax/Bcl-2) in cardiomyocytes of diabetic rats after combined exercise training and taurine supplementation
Different modalities of exercise improve cardiac function in diabetes. This study evaluated the effects of Taurine supplementation plus endurance and...
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Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo
Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized....
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Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both
Treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with mutation-selective third-generation EGFR-tyrosine kinase inhibitors (EGFR-TKIs) such...
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Elevated Bax/Bcl-2 Ratio: A Cytotoxic Mode of Action of Kermanian Propolis Against an Acute Lymphoblastic Leukemia Cell Line, NALM-6
Currently, alternative cancer remedies, especially herbal-derived medicines, have attracted great interest. Propolis, a honeybee-produced...
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Amaranthus viridis methanolic extract and its active compound kaempferol ameliorate myocardial infarction induced by isoproterenol through decreasing oxidative stress and cell death via Nrf-2/HO-1 and MMP/Bax/Bcl-2/TLR-4 pathways in rats
The cardioprotective impact of Amaranthus viridis methanolic extracts (AVMEs) and its active phytoconstituent kaempferol on isoproterenol...
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Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment
BackgroundMicroRNA (miRNA) plays a vital role in the intervertebral disc (IVD) degeneration. The expression level of miR-573 was downregulated...
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PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells
BackgroundCisplatin-induced injury of renal proximal tubular cells results basically from increased apoptosis via mitochondrial damage, and is...
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NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX
NORE1A (RASSF5) is a tumor suppressor of the Ras-association domain family (RASSF) that is commonly inactivated in multiple human cancers. However,...
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Role of phototherapy, BAX gene expression in hyperbilirubinemia development in full-term neonates
BackgroundPhototherapy is the main therapeutic interference for neonatal hyperbilirubinemia used to escape an exchange transfusion and to decrease...
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Short-term postmortem interval estimation by detection of apoptosis-related protein in skin
Time-of-death extrapolation has always been one of the most important issues in forensic practice. For a complicated case in which a corpse is...
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What is the role of CHCHD2 in adrenal tumourigenesis?
PurposeCHCHD2 is an antiapoptotic mitochondrial protein acting through the BCL2/BAX pathway in various cancers. However, data on the regulatory role...
