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Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment
IntroductionBortezomib (BTZ) is a selective and reversible proteasome inhibitor and first line treatment for multiple myeloma (MM). One of the side...
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Neurofilament light chains in serum as biomarkers of axonal damage in early MS lesions: a histological–serological correlative study
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL)...
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Inhibition of p38 ameliorates axonal loss with modulation of autophagy in TNF-induced optic nerve damage
PurposeA relationship between p38 and autophagy remains debated. The aim of the current study is to investigate whether an inhibitor of p38 prevents...
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Sex differences in the extent of acute axonal pathologies after experimental concussion
Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With...
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Association between hyperCKemia and axonal degeneration in Guillain–Barré syndrome
BackgroundElevated serum creatine kinase (CK) levels have been reported in patients with Guillain–Barré syndrome (GBS), more frequently in patients...
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Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration
PurposeThe ROCK inhibitor ripasudil hydrochloride hydrate was shown to have axonal protective effects in TNF-induced optic nerve degeneration. The...
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Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
Traumatic brain injury (TBI) has high morbidity and poor prognosis and imposes a serious socioeconomic burden. Traumatic axonal injury (TAI), which...
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Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier
Despite being a major health concern, little is known about the pathophysiological changes that underly concussion. Nonetheless, emerging evidence...
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Serum neurofilament levels correlate with electrodiagnostic evidence of axonal loss in paclitaxel-induced peripheral neurotoxicity
IntroductionPaclitaxel-induced peripheral neurotoxicity (PIPN) typically manifests as a predominantly sensory axonopathy. Nerve conduction studies...
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Role of integrin and its potential as a novel postmortem biomarker in traumatic axonal injury
Traumatic axonal injury (TAI) accounts for a large proportion of the mortality of traumatic brain injury (TBI). The diagnosis of TAI is currently of...
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Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem
ObjectiveApplication of Tandem Mass Tags (TMT)-based LC–MS/MS analysis to screen for differentially expressed proteins (DEPs) in traumatic axonal...
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Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury
BackgroundIt is known that blood levels of neurofilament light (NF-L) and diffusion-weighted magnetic resonance imaging (DW-MRI) are both associated...
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Advanced diffusion MRI provides evidence for altered axonal microstructure and gradual peritumoral infiltration in GBM in comparison to brain metastases
PurposeIn contrast to peritumoral edema in metastases, GBM is histopathologically characterized by infiltrating tumor cells within the T2 signal...
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Axonal injury is detected by βAPP immunohistochemistry in rapid death from head injury following road traffic collision
The accumulation of βAPP caused by axonal injury is an active energy-dependent process thought to require blood circulation; therefore, it is closely...
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Parkinsonism in spinocerebellar ataxia with axonal neuropathy caused by adult-onset COA7 variants: a case report
BackgroundIndividuals with variants of cytochrome c oxidase assembly factor 7 ( COA7 ), a mitochondrial functional-related gene, exhibit symptoms of...
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Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma
BackgroundPost severe traumatic brain injury (sTBI), axonal alterations lead to myelin loss and its degeneration. In the recovery phase, numerous...
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Toxic leukoencephalopathy with axonal spheroids caused by chemotherapeutic drugs other than methotrexate
BackgroundThe objective of this report is to share the clinicopathological features of chemotherapy-induced toxic leukoencephalopathy, which is a...
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Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy
Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders, including multiple sclerosis. Here, we report altered...
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Acrodystrophic axonal polyneuropathy with celiac disease: a case report
BackgroundPatients with celiac disease present with not only gastrointestinal symptoms but also extraintestinal manifestations such as anemia,...
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Bu Shen Huo Xue decoction promotes functional recovery in spinal cord injury mice by improving the microenvironment to promote axonal regeneration
BackgroundBu-Shen-Huo-Xue (BSHX) decoction has been used in the postoperative rehabilitation of patients with spinal cord injury in China. In the...
