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Transformation of Chronic Lymphocytic Leukemia into Acute Mixed Phenotype Leukemia Myeloid/T Neoplasm: a Case Report
Chronic lymphocytic leukemia (CLL) is defined by the presence of lymphocyte in the blood, bone marrow, lymph nodes, and spleen, with a median...
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t(1;4) translocation in a child with acute lymphoblastic leukemia: a case report
BackgroundAcute lymphoblastic leukemia is the most common childhood cancer, with an 80% frequency in children between 1 and 10 years old. The outcome...
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Th1 cytokines in pediatric acute lymphoblastic leukemia
Immune milieus play an important role in various types of cancer. The present study focuses on the effect of Th1 cytokines on pediatric acute...
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Xeroderma pigmentosum and acute myeloid leukemia: a case report
BackgroundXeroderma pigmentosum is a rare inherited disease characterized by extreme hypersensitivity to ultraviolet rays and predisposing to...
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Primary Mold-Active Antifungal Prophylaxis Decreases the Need for Chest Computed Tomography Scans in Patients with Acute Lymphoblastic Leukemia
Current guidelines recommend computed tomography (cCT) scans of the chest in children with leukemia following 96 h of the onset of idiopathic...
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Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms
CFI-400945 is a selective oral polo-like kinase 4 (PLK4) inhibitor that regulates centriole duplication. PLK4 is aberrantly expressed in patients...
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Cardiac electrical abnormalities in childhood acute lymphoblastic leukemia survivors: a systematic review
PurposeThe aim was to provide evidence about the prevalence, incidence, and risk factors of cardiac electrical abnormalities in childhood acute...
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Unrelated hematopoietic stem cell transplantation for familial platelet disorder/acute myeloid leukemia with germline RUNX1 mutations
Germline mutations in RUNX1 result in rare autosomal-dominant familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). As...
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Prevalence of hopelessness and suicidal ideation and their associated factors among pediatric patients with leukemia
BackgroundWith the increasing survival rate of pediatric patients with leukemia, improving their quality of life (QoL) is the new challenge....
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Measurable residual disease study through three different methods can anticipate relapse and guide early interventions in childhood acute lymphoblastic leukemia
IntroductionAcute lymphoblastic leukemia (ALL) is the most common cancer among children. Measurable residual disease (MRD, previously named minimal...
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Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in...
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Reduce proliferation of human bone marrow cells from acute myeloblastic leukemia with minimally differentiation by blocking lncRNA PVT1
PurposeAcute myeloblastic leukemia with minimally differentiation (AML-M0) is a subtype of acute leukemia with poor prognosis. The recent studies...
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Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies
The members of the Poly(ADP‐ribose) polymerase (PARP) superfamily are involved in several biological processes and, in particular, in the DNA damage...
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Measurable residual disease study through three different methods can anticipate relapse and guide pre-emptive therapy in childhood acute myeloid leukemia
PurposeAlthough outcomes of children with acute myeloid leukemia (AML) have improved over the last decades, around one-third of patients relapse....
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Monocytosis and Multiple Myeloma: treatment-related acute leukaemia?
BackgroundTherapy-related acute monocytic leukemias in patients with plasma cell dyscrasias are infrequent.
Case presentationWe here present a case...
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Evolution of eligibility criteria for non-transplant randomized controlled trials in adults with acute myeloid leukemia
Eligibility criteria for clinical trials are intended to select suitable study subjects but can limit trial participation and generalization of...
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All-trans retinoic acid induces differentiation in primary acute myeloid leukemia blasts carrying an inversion of chromosome 16
All- trans retinoic acid (ATRA)-based therapy for acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is the most...
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Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis
CRISPR-mediated simultaneous targeting of candidate tumor suppressor genes in Xenopus tropicalis allows fast functional assessment of co-driver genes...
