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Video-EEG-monitoring to guide antiseizure medication withdrawal
BackgroundDiscontinuing anti-seizure medication (ASM) should be considered in persons with epilepsy with long-term seizure freedom. Clinicians should...
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Pharmacological Treatment of GHB Withdrawal Syndrome
Purpose of ReviewGamma-hydroxybutyrate (GHB) is an illicit drug used for many reasons: during music festivals or parties, for self-management of...
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Neurological update: non-motor symptoms in atypical parkinsonian syndromes
Among people with Parkinson’s disease (PD), non-motor symptoms (NMS) are a well-recognised cause of significant morbidity and poor quality of life....
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Heterogeneity of Autism Characteristics in Genetic Syndromes: Key Considerations for Assessment and Support
Purpose of ReviewElevated prevalence of autism characteristics is reported in genetic syndromes associated with intellectual disability. This review...
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Differences in Psychological Health and Weight Loss after Bariatric Metabolic Surgery between Patients with and without Pain Syndromes
PurposeChronic pain and obesity often co-occur, negatively affecting one another and psychological wellbeing. Pain and psychological wellbeing...
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Estimating Risk of Antidepressant Withdrawal from a Review of Published Data
Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The outcome of adaptation is often referred to as ‘physical...
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Psychosocial stress, interpersonal sensitivity, and social withdrawal in clinical high risk for psychosis: a systematic review
Stress has repeatedly been implicated in the onset and exacerbation of positive symptoms of psychosis. Increasing interest is growing for the role of...
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Management of Tizanidine Abuse and Withdrawal in a 53-Year-Old Woman: a Case Report
Whilst tizanidine is commonly used, withdrawal has been very rarely documented. This case is unique as the patient we present had been taking higher...
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Antiseizure Medication Withdrawal in Seizure-Free Patients: What is New for the Pediatrician?
The American Academy of Neurology (AAN) has recently updated its practise advisory on antiseizure medication withdrawal. The recommendations have...
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Cannabinoid hyperemesis syndrome and cannabis withdrawal syndrome: a review of the management of cannabis-related syndrome in the emergency department
BackgroundCannabis-related medical consultations are increasing worldwide, a non-negligible public health issue; patients presenting to acute care...
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Fenfluramine in clinical practice: new therapy option for Dravet and Lennox–Gastaut syndromes
Fenfluramine is an antiseizure medication for the treatment of Dravet and Lennox–Gastaut syndromes. This review summarizes the literature on the...
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21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology
BackgroundBiotechnological syndromes refer to the illnesses that arise at the intersection of human physiology and digital technology. Now that we...
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Withdrawal Syndrome Following Discontinuation of 28 Antidepressants: Pharmacovigilance Analysis of 31,688 Reports from the WHO Spontaneous Reporting Database
IntroductionEvidence is lacking on withdrawal syndrome related to individual antidepressants and relevant risk factors for severe reactions.
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Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database
BackgroundIntravenous dantrolene is often prescribed for hypermetabolic syndromes other than the approved indication of malignant hyperthermia (MH)....
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Central Neuropathic Pain Syndromes: Current and Emerging Pharmacological Strategies
Central neuropathic pain is caused by a disease or lesion of the brain or spinal cord. It is difficult to predict which patients will develop central...
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Rapid versus slow withdrawal of antiepileptic monotherapy in two-year seizure-free adults patients with epilepsy (RASLOW) study: A pragmatic multicentre, prospective, randomized, controlled study
PurposeTo establish whether a slow or a rapid withdrawal of antiepileptic monotherapy influences relapse rate in seizure-free adults with epilepsy...
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Oxytocin-based therapies for treatment of Prader-Willi and Schaaf-Yang syndromes: evidence, disappointments, and future research strategies
The prosocial neuropeptide oxytocin is being developed as a potential treatment for various neuropsychiatric disorders including autism spectrum...
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The Impact of CYP2C19 Genotype on the Platelet Reactivity Index (PRI) among Chronic Coronary Syndromes (CCS) Patients Undergoing Percutaneous Coronary Intervention (PCI): Affectability of Rapid Genetic Testing
BackgroundIn the Asian population, the presence of the CYP2C19 loss-of-function (LOF) allele is a known genetic variation. This allele is associated...
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Implications of dopaminergic medication withdrawal in Parkinson’s disease
The trajectory of the use of dopamine replacement therapy (DRT) in Parkinson’s disease (PD) is variable and doses may need to be increased, but also...
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Depressive symptoms and malnutrition are associated with other geriatric syndromes and increase risk for 30-Day readmission in hospitalized older adults: a prospective cohort study
BackgroundReadmission in older adults is typically complex with multiple contributing factors. We aim to examine how two prevalent and potentially...
