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Molecular mechanism of Wilms’ tumor (Wt1) (+/−KTS) variants promoting proliferation and migration of ovarian epithelial cells by bioinformatics analysis
Epithelial ovarian cancer (EOC) is a gynecological disease with the highest mortality. With the lack of understanding of its pathogenesis, no...
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Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
IntroductionThe peptide-based cancer vaccine targeting Wilms’ tumor 1 (WT1) is a promising immunotherapeutic strategy for hematological malignancies....
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A review of the genetic background in complicated WT1-related disorders
The Wilms tumor 1 ( WT1 ) gene was first identified in 1990 as a strong candidate for conferring a predisposition to Wilms tumor. The WT1 protein has...
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Wilms tumor 1 gene expression in acute myeloid leukemia: prognostic significance and usefulness in minimal residual disease monitoring—a case–control study
BackgroundMinimal residual disease (MRD), which is characterized as leukemic cells at a level below morphologic detection, has been connected to the...
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WT1 gene mutations impact post-transplant relapse in myelodysplastic syndrome with excess blasts 2 patients
Wilms tumor 1 ( WT1 ) gene mutations are infrequent in myelodysplastic syndrome (MDS), but MDS with WT1 mutations (WT1 mut ) is considered high risk for...
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Differential expression profiling of onco and tumor-suppressor genes from major-signaling pathways in Wilms’ tumor
PurposeWilms’ tumor is the most-frequent malignant-kidney tumor in children under 3–4 years of age and is caused by genetic alterations of oncogenes...
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WT1-guided pre-emptive therapy after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia
Measurable residual disease (MRD)-guided pre-emptive therapies are now widely used to prevent post-transplant hematological relapse in patients with...
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WT1-related disorders: more than Denys-Drash syndrome
Historically, specific mutations in WT1 gene have been associated with distinct syndromes based on phenotypic characteristics, including Denys-Drash...
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Evaluation of pathogenicity of WT1 intron variants by in vitro splicing analysis
BackgroundWilms tumor 1 ( WT1 ; NM_024426) causes Denys–Drash syndrome, Frasier syndrome, or isolated focal segmental glomerulosclerosis. Several WT1 ...
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Prognostic impact of peripheral blood WT1 mRNA dynamics in patients with acute myeloid leukemia treated with venetoclax combination therapy
BackgroundWilms' tumor gene 1 ( WT1 ) mRNA quantification is a useful marker of measurable residual disease in acute myeloid leukemia (AML). However,...
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Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor
ObjectivesWilms tumor (WT) is a common renal malignant tumor in children. We aimed to investigate the potential prognostic value of m6A-related genes...
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Hallmark discoveries in the biology of Wilms tumour
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ model of tumour development. Since...
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A case of Potter sequence with WT1 mutation
Wilms tumor 1 ( WT1 ) is the causative gene of Denys–Drash syndrome and Frasier syndrome, and in most cases, kidney failure develops after birth. We...
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Dual targeting ovarian cancer by Muc16 CAR T cells secreting a bispecific T cell engager antibody for an intracellular tumor antigen WT1
Epithelial ovarian cancer is the most lethal of gynecological cancers. The therapeutic efficacy of chimeric antigen receptor (CAR) T cell directed...
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WT1 exon 10 missense variant in a pediatric patient with focal segmental glomerulosclerosis with embryonal hyperplasia
A 6-year-old boy was diagnosed with chromosomal abnormalities (48,XYY, + 21[11]/46,XY[19]) at 4 months of age after a physical examination revealed...
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Wilms Tumor 1-Associated Protein Expression Is Linked to a T-Cell-Inflamed Phenotype in Pancreatic Cancer
BackgroundThe molecular driving forces of anti-tumor immunity in pancreatic ductal adenocarcinoma (PDAC) remain unclear, which causing great...
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Long-term kidney function in children with Wilms tumour and constitutional WT1 pathogenic variant
BackgroundWilms tumour (WT) survivors, especially patients with associated syndromes or genitourinary anomalies due to constitutional WT1 pathogenic...
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Efficacy analysis of multidisciplinary treatment for Wilms tumor in a single center
ObjectiveTo analyze the efficacy of multidisciplinary treatment for Wilms tumor (WT) in Kunming Children’s Hospital, and investigate the risk factors...
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Isolated steroid-resistant nephrotic syndrome in a Chinese child carrying a de novo mutation in WT1 gene:a case report and literature review
BackgroundIsolated steroid-resistant nephrotic syndrome (ISRNS) is caused by mutations in the Wilms’ tumor-1 (WT1) gene, which encodes glomerular...
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Obesity-related glomerulopathy is associated with elevated WT1 expression in podocytes
BackgroundThe prevalence of obesity is increasing worldwide at an alarming rate. In addition to the increased incidence of cardiovascular and...
