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Weibel-Palade bodies: function and role in thrombotic thrombocytopenic purpura and in diarrhea phase of STEC-hemolytic uremic syndrome
AbstractVascular endothelial cells are equipped with numerous specialized granules called Weibel-Palade bodies (WPBs). They contain a cocktail of...
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Identifying different patterns of emotion dysregulation in adult ADHD
BackgroundEmotion dysregulation (ED) is a core intrinsic feature of adult presenting Attention Deficit Hyperactivity Disorder (ADHD). However, the...
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Include or not to include conference abstracts in systematic reviews? Lessons learned from a large Cochrane network meta-analysis including 585 trials
BackgroundSystematic reviews attempt to gather all available evidence. Controversy exists regarding effort and benefit of including study results...
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Regulation of von Willebrand factor by ADAMTS13 ameliorates lipopolysaccharide-induced lung injury in mice
The relationship between von Willebrand factor (VWF) and inflammation has attracted considerable attention in recent years. VWF, which is stored in...
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Pathological findings of myocardium in a patient with cardiac conduction defect associated with an SCN5A mutation
A 16-year-old Japanese man was admitted to our hospital because of syncope during exercise. His father and his younger brother had permanent...
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Compassion-focused therapy (CFT) for the reduction of the self-stigma of mental disorders: the COMpassion for Psychiatric disorders, Autism and Self-Stigma (COMPASS) study protocol for a randomized controlled study
BackgroundPeople with mental disorders face frequent stigmatizing attitudes and behaviors from others. Importantly, they can internalize such...
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Update PONV – Was gibt es Neues bei der Prophylaxe und Therapie von postoperativer Übelkeit und postoperativem Erbrechen?
The prophylaxis and treatment of postoperative pain to enhance patient comfort has been a primary goal of anesthesiologists for the last decades;...
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Transdiagnostic skills training group of dialectical behavior therapy: a long-term naturalistic study
IntroductionDialectical Behavior Therapy (DBT) has assembled a large body of evidence for the treatment of emotional dysregulation in borderline...
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Comparison of dose–response to two different doses of intravenous lidocaine for analgesia in patients undergoing elective laparoscopic cholecystectomy under general anesthesia
BackgroundVarious studies have demonstrated the analgesic benefit of systemic lidocaine in the perioperative setting, especially during laparoscopic...
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Immunohistochemistry Data on the Structural and Functional Changes in the Vascular Endothelium of the Heart of Old Rats
AbstractThe goal of the study was to investigate the morphofunctional changes of the vascular endothelium in different parts of the heart of aging...
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The critical role of endothelial cell in the toxicity associated with chimeric antigen receptor T cell therapy and intervention strategies
Chimeric antigen receptor (CAR)-T cell therapy has shown promising results in patients with hematological malignancies. However, many patients still...
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A Sco** Review of the Efficacy and Safety of Methotrexate Compared to Mycophenolate Mofetil in the Treatment of Juvenile Localized Scleroderma in Children and Young Adults
Juvenile localised scleroderma (JLS) is a condition that results in inflammation and fibrosis of the skin in children and young people. Systemic...
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Model selection for component network meta-analysis in connected and disconnected networks: a simulation study
BackgroundNetwork meta-analysis (NMA) allows estimating and ranking the effects of several interventions for a clinical condition. Component network...
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The roles of P-selectin in cancer cachexia
P -selectin, a cell adhesion molecule of the selectin family, is expressed on the surface of activated endothelial cells (ECs) and platelets. Binding...
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A new, deep learning–based method for the analysis of autopsy kidney samples used to study sex differences in glomerular density and size in a forensic population
Artificial intelligence (AI) is increasingly used in forensic anthropology and genetics to identify the victim and the cause of death. The large...
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Expression and significance of SIRT6 in human peritoneal dialysis effluents and peritoneal mesothelial cells
Sirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal...
