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1. Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes

   Dopaminergic signaling in the nucleus accumbens shell (NAc) regulates neuronal activity relevant to reward-related learning, including...

   Mengfan **a, Tanner L. Anderson, ... Pavel I. Ortinski in Neuropsychopharmacology

   Article 02 September 2023
   

2. Expression of voltage-gated Ca²⁺ channels, Insp₃Rs, and RyRs in the immature mouse ovary

   Background

   The postnatal mammalian ovary undergoes a series of changes to ensure the maturation of sufficient follicles to support ovulation and...

   Daniel Bahena-Alvarez, Diana Millan-Aldaco, ... Arturo Hernandez-Cruz in Journal of Ovarian Research

   Article Open access 22 July 2022
   

3. l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels

   Background

   We previously reported that, among all the naturally occurring amino acids, l -valine is the most powerful luminal stimulator of...

   Ida Marie Modvig, Mark M. Smits, ... Jens Juul Holst in Nutrition & Diabetes

   Article Open access 11 June 2024
   

4. A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism

   Background

   Novel developmental mutations associated with disease are a continuous challenge in medicine. Clinical consequences caused by these...

   Jesús Galán-Vidal, Paula G. Socuéllamos, ... Alberto Gandarillas in Orphanet Journal of Rare Diseases

   Article Open access 06 September 2022
   

5. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

   Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare...

   Chenyao Wang, Shin-ichiro Horigane, ... Norio Ozaki in Translational Psychiatry

   Article Open access 26 February 2022
   

6. Amlodipine and Verapamil, Voltage-Gated Ca²⁺ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells

   Background

   The membrane transporters activated in cancer stem cells (CSCs) are the target of novel cancer therapies for gastric cancer. The present...

   Atsushi Shiozaki, Keita Katsurahara, ... Eigo Otsuji in Annals of Surgical Oncology

   Article 10 February 2021
   

7. Polymorphisms of the sodium voltage-gated channel, alpha subunit 1 (SCN1A -A3184G) gene among children with non-lesional epilepsy: a case-control study

   Background

   Mutations in the neuronal sodium voltage-gated channel, alpha subunit 1 ( SCN1A) gene have been associated with epilepsy. We investigated...

   Esraa Ghazala, Doaa A. Shahin, Yahya Wahba in Italian Journal of Pediatrics

   Article Open access 02 September 2022
   

8. Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/Culex pipiens quinquefasciatus in China

   Background

   Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease...

   Wenyu Li, Delong Ma, ... Fengxia Meng in Infectious Diseases of Poverty

   Article Open access 15 April 2024
   

9. Hesperetin Relaxes Depolarizing Contraction in Human Umbilical Vein by Inhibiting L-Type Ca²⁺ Channel

   Objective

   To study hesperetin-induced vasorelaxation after depolarizing contraction in human umbilical veins (HUVs) to elucidate the role of L-type Ca

   Kritsana Tipcome, Wattana B. Watanapa, Katesirin Ruamyod in Chinese Journal of Integrative Medicine

   Article 18 January 2024

10. Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of Ca_V1.2 calcium channel

    The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the Ca _V 1.2 channel is a prominent risk gene for neuropsychiatric and...

    Sheeja Navakkode, **g Zhai, ... Tuck Wah Soong in Translational Psychiatry

    Article Open access 10 January 2022
    

11. Pulmonary Circulation Under Pressure: Pathophysiological and Therapeutic Implications of BK Channel

    The large-conductance Ca ²⁺ -activated K ⁺ (BK) channel is widely expressed in the pulmonary blood vessels and plays a significant role in regulating...

    Thais S. Barenco-Marins, Fernando A. C. Seara, ... Jose H. M. Nascimento in Cardiovascular Drugs and Therapy

    Article 25 August 2023
    

12. ASO Author Reflections: Amlodipine and Verapamil, Voltage-Gated Ca²⁺ Channel Inhibitors Suppressed the Growth of Gastric Cancer Stem Cells

    Atsushi Shiozaki, Keita Katsurahara, Eigo Otsuji in Annals of Surgical Oncology

    Article 08 February 2021

13. InsP₃R–RyR Ca²⁺ channel crosstalk facilitates arrhythmias in the failing human ventricle

    Dysregulated intracellular Ca ²⁺ handling involving altered Ca ²⁺ release from intracellular stores via RyR channels underlies both arrhythmias and...

    **n **, Matthew Amoni, ... H. Llewelyn Roderick in Basic Research in Cardiology

    Article 15 November 2022
    

14. Ca²⁺ channel blockade reduces cocaine’s vasoconstriction and neurotoxicity in the prefrontal cortex

    Cocaine profoundly affects both cerebral blood vessels and neuronal activity in the brain. The vasoconstrictive effects of cocaine, concurrently with...

    Congwu Du, Kicheon Park, ... Yingtain Pan in Translational Psychiatry

    Article Open access 06 September 2021
    

15. The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants

    Major depressive disorder (MDD) is a leading cause of disability worldwide and less than one-third of patients with MDD achieve stable remission of...

    Sara Costi, Ming-Hu Han, James W. Murrough in CNS Drugs

    Article 08 March 2022
    

16. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

    Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different...

    Miao Zhang, Yueming Ma, ... Bing Wang in Signal Transduction and Targeted Therapy

    Article Open access 05 July 2023
    

17. Design of an Imaging Probe to Monitor Real-Time Redistribution of L-type Voltage-Gated Calcium Channels in Astrocytic Glutamate Signaling

    Purpose

    In the brain, astrocytes are non-excitable cells that undergo rapid morphological changes when stimulated by the excitatory neurotransmitter...

    Mitra Sadat Tabatabaee, Jeff Kerkovius, Frederic Menard in Molecular Imaging and Biology

    Article 12 January 2021
    

18. Developmental oxidative stress leads to T-type Ca²⁺ channel hypofunction in thalamic reticular nucleus of mouse models pertinent to schizophrenia

    Impairment of parvalbumin interneurons induced by oxidative stress (OxS) is a “hub” on which converge several genetic and environmental risk factors...

    Corinne El Khoueiry, Jan-Harry Cabungcal, ... Pascal Steullet in Molecular Psychiatry

    Article Open access 25 January 2022
    

19. Role of peroxisome proliferators-activated receptor-gamma in advanced glycation end product-mediated functional loss of voltage-gated potassium channel in rat coronary arteries

    Background

    High blood glucose impairs voltage-gated K ⁺ (Kv) channel-mediated vasodilation in rat coronary artery smooth muscle cells (CSMCs) via...

    Side Gao, Bing Hua, ... Hongwei Li in BMC Cardiovascular Disorders

    Article Open access 14 July 2020
    

20. The anti-tumor drug 2-hydroxyoleic acid regulates the oncogenic potassium channel Kv10.1

    Background

    2-hydroxyoleic acid (2OHOA) is a synthetic fatty acid with antitumor properties that alters membrane composition and structure, which in...

    Rita Morán-Zendejas, Aldo A. Rodríguez-Menchaca in Beni-Suef University Journal of Basic and Applied Sciences

    Article Open access 03 February 2023