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Canine distemper virus N protein induces autophagy to facilitate viral replication
BackgroundCanine distemper virus (CDV) is one of the most contagious and lethal viruses known to the Canidae , with a very broad and expanding host...
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Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
Duck Tembusu virus (DTMUV) is a neurotropic virus in the genus Flavivirus that causes massive economic losses to the poultry industry in China and...
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Roles of ANP32 proteins in cell biology and viral replication
The acidic leucine-rich nuclear phosphoprotein 32 kDa (ANP32) family consists of evolutionarily conserved proteins of 220–291 amino acids...
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HSP70 positively regulates translation by interacting with the IRES and stabilizes the viral structural proteins VP1 and VP3 to facilitate duck hepatitis A virus type 1 replication
The maintenance of viral protein homeostasis depends on the interaction between host cell proteins and viral proteins. As a molecular chaperone, heat...
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SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication
Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of...
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Interleukin-22 facilitates the interferon-λ-mediated production of tripartite motif protein 25 to inhibit replication of duck viral hepatitis A virus type 1
The innate immune system provides a defense against invading pathogens by inducing various interferon (IFN)-stimulated genes (ISGs). We recently...
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Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells
Orf virus (ORFV) is the causative agent of contagious ecthyma, which is an important zoonotic pathogen with a widespread distribution affecting...
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A novel strategy to attenuate porcine reproductive and respiratory syndrome virus by inhibiting viral replication in the target pulmonary alveolar macrophages via hematopoietic-specific miR-142
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified...
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Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replication
Canine distemper (CD) is a highly contagious and an acutely febrile disease caused by canine distemper virus (CDV), which greatly threatens the dog...
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A novel amino acid site of N protein could affect the PRRSV-2 replication by regulating the viral RNA transcription
BackgroundFinding the key amino acid sites that could affect viral biological properties or protein functions has always been a topic of substantial...
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Porcine parvovirus triggers autophagy through the AMPK/Raptor/mTOR pathway to promote viral replication in porcine placental trophoblasts
Autophagy has been demonstrated to play important roles in the infection and pathogenesis of many viruses. We previously found that porcine...
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SARS-CoV-2 viral load and replication in postmortem examinations
We examined 29 autopsy cases (investigated between October 2020 and February 2021) whose postmortem swabs tested positive for SARS-CoV-2. Twenty-two...
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A review on hepatitis C virus: role of viral and host-cellular factors in replication and existing therapeutic strategies
BackgroundHepatitis C virus, a member of Flaviviridae is a single-stranded positive-sense RNA virus infecting 62–79 million people around the globe....
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RNA binding protein TIAR modulates HBV replication by tip** the balance of pgRNA translation
The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves not only as a bicistronic message RNA to translate core protein (Cp) and DNA polymerase...
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Interleukin-2 enhancer binding factor 2 negatively regulates the replication of duck hepatitis A virus type 1 by disrupting the RNA-dependent RNA polymerase activity of 3D polymerase
The interaction between viral components and cellular proteins plays a crucial role in viral replication. In a previous study, we showed that the...
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MiR-320 inhibits PRRSV replication by targeting PRRSV ORF6 and porcine CEBPB
Porcine reproductive and respiratory syndrome (PRRS), a highly contagious disease caused by Porcine reproductive and respiratory syndrome virus...
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Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding
Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral...
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Tumor necrosis factor-alpha blockade suppresses BK polyomavirus replication
PurposeBK Polyomavirus (BKPyV) infection manifests as renal inflammation and can cause kidney damage. Tumor necrosis factor-α (TNF-α) is increased in...
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Neurons cytoskeletal architecture remodeling during the replication cycle of mouse coronavirus MHV-JHM: a morphological in vitro study
Nowadays, the population is still struggling with a post-COVID19 syndrome known as long COVID, including a broad spectrum of neurological problems....
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Impaired immune responses and prolonged viral replication in lung allograft recipients infected with SARS-CoV-2 in the early phase after transplantation
PurposeLung transplant recipients are at increased risk of severe disease following infection with severe acute respiratory syndrome coronavirus type...
