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Understanding the mechanisms of ventilator-induced lung injury using animal models
Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest to the respiratory muscles....
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Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur...
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Electroacupuncture alleviates ventilator-induced lung injury in mice by inhibiting the TLR4/NF-κB signaling pathway
ObjectiveThis study was aimed to explore the protective effect of electroacupuncture (EA) pretreatment at Zusanli point (ST36) on ventilation-induced...
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Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice
BackgroundMechanical ventilation is a supportive therapy used to maintain respiratory function in several clinical and surgical cases but is always...
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Alveolar macrophage-derived gVPLA2 promotes ventilator-induced lung injury via the cPLA2/PGE2 pathway
BackgroundVentilator-induced lung injury (VILI) is a clinical complication of mechanical ventilation observed in patients with acute respiratory...
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Aerobic exercise alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation
BackgroundVentilator-induced lung injury (VILI) is caused by stretch stimulation and other factors related to mechanical ventilation (MV). NOD-like...
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A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
BackgroundAnimal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We...
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Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
BackgroundVentilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of...
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NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model
BackgroundFor patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung...
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Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury
BackgroundModels of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation...
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c-Fos is a mechanosensor that regulates inflammatory responses and lung barrier dysfunction during ventilator-induced acute lung injury
BackgroundAs one of the basic treatments performed in the intensive care unit, mechanical ventilation can cause ventilator-induced acute lung injury...
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Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats
BackgroundMechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced lung injury (VILI). Piezo1 is a key element...
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A role for bronchial epithelial autotaxin in ventilator-induced lung injury
BackgroundThe pathophysiology of acute respiratory distress syndrome (ARDS) may eventually result in heterogeneous lung collapse and edema-flooded...
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Effect and mechanical mechanism of spontaneous breathing on oxygenation and lung injury in mild or moderate animal ARDS
ObjectiveThe present study aimed to determine the effect and mechanical mechanism of spontaneous breathing during mechanical ventilation on...
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The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury
BackgroundVentilator-induced lung injury (VILI) is a common complication in the treatment of respiratory diseases with high morbidity and mortality....
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Inhibition of MicroRNA-214 Alleviates Lung Injury and Inflammation via Increasing FGFR1 Expression in Ventilator-Induced Lung Injury
PurposeVentilator-induced lung injury (VILI) is an additional inflammatory injury caused by mechanical ventilation (MV). This study aimed to...
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Advances in multimodal imaging of lung injury
Lung injury is caused by various physical and chemical damages that lead to the destruction of the structural integrity or dysfunction of the lungs,...
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Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial...
