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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the transformation of the soft and...
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Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine-induced hypo-vascularization
PurposePancreatic ductal adenocarcinoma (PDAC) is a molecularly heterogeneous tumor entity with no clinically established imaging biomarkers. We...
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Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors
Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of...
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Confocal laser endomicroscopy in glial tumors—a histomorphological analysis
ObjectiveThe extent of resection and neurological outcome are important prognostic markers for overall survival in glioma patients. Confocal laser...
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Robot-assisted resection of benign splenic tumors in children
PurposeRobotic surgery is becoming increasingly widely used in the field of pediatric surgery. The present study aimed to evaluate the safety and...
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Diagnosis and monitoring denosumab therapy of giant cell tumors of bone: radiologic-pathologic correlation
ObjectiveTo determine the value of CT and dynamic contrast-enhanced (DCE-)MRI for monitoring denosumab therapy of giant cell tumors of bone (GCTB) by...
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Case series of extradigital glomus tumors: imaging findings, differential diagnosis and radiologic–pathologic correlation
BackgroundGlomus tumors are benign mesenchymal tumors of the neuromyoarterial glomus bodies. They are generally localized at the subungual area of...
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Transcatheter Arterial Embolization Combined with Anti-vascular Agent Combretastatin A4 Phosphate Inhibits Growth and Vascularization of Liver Tumor in an Animal Model
ObjectiveThis study aimed to investigate the effect of combretastatin A4 phosphate (CA4P) on proliferation, migration, and capillary tube formation...
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Bone tumors: state-of-the-art imaging
Imaging plays a central role in the management of patients with bone tumors. A number of imaging modalities are available, with different techniques...
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Diagnosis and treatment of malignant eyelid tumors
BackgroundMalignant tumors of the eyelid are much less frequent than benign eyelid alterations. These are frequently incidental findings without...
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Perfusion analysis of benign parotid gland tumors by contrast-enhanced ultrasonography (CEUS)
BackgroundDiagnosis of parotid gland tumors is sometimes challenging due to their diversity and pleomorphic histological appearance. B-scan...
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Brachial plexus peripheral nerve sheath tumors (PNSTs): clinical and surgical management in the pediatric population
PurposePeripheral nerve sheath tumors (PNSTs) are rare in pediatric patients, especially in the brachial plexus. Research on PNSTs is lacking. This...
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Targeting tumor vascularization: promising strategies for vascular normalization
Tumor recurrence after the clinical cure of tumor often results from the presence of an abnormal microenvironment, including an aberrant vasculature....
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Imaging Techniques to Differentiate Benign Testicular Masses from Germ Cell Tumors
Purpose of ReviewTo discuss role of different diagnostic imaging modalities in differentiation of benign testicular masses from seminomatous germ...
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Identification of Pediatric Tumors Intraoperatively Using Indocyanine Green (ICG)
BackgroundFluorescence-guided surgery (FGS) with indocyanine green (ICG) is increasingly applied in pediatric surgical oncology. However, FGS has...
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TFE3 nuclear expression as a novel biomarker of ovarian sclerosing stromal tumors and associated with its histological morphology
Sclerosing stromal tumors of the ovary are benign and tend to occur in youthful women with lobular structures at low frequencies. Three types of...
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Recent progress of experimental model in pancreatic neuroendocrine tumors: drawbacks and challenges
The neuroendocrine neoplasm, in general, refers to a heterogeneous group of all tumors originating from peptidergic neurons and neuroendocrine cells....
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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors
Purpose of ReviewThis review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs....
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Multicenter retrospective study on benign testicular tumors in children: save as much as you can……please
BackgroundTesticular tumors (TT) are infrequent in pediatric patients, representing 1% of pediatric solid tumors; benign testicular tumors (BTT) are...
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Exoscopic microneurosurgery in pediatric brain tumors: an ideal tool for complex and peculiar anatomo-topographic scenarios?
PurposeSince its introduction in the 1950s, the microsurgical paradigm has revolutionized neurosurgery. New technologies have been introduced over...
