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1. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

   It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role...

   L. Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, ... Xosé R. Bustelo in Oncogene

   Article Open access 09 May 2022
   

2. Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia

   Aberrant RHO guanine nucleotide exchange factor (RhoGEF) activation is chief mechanism driving abnormal activation of their GTPase targets in...

   Shailaja Hegde, Anjelika Gasilina, ... Nicolas N. Nassar in Leukemia

   Article Open access 28 October 2021
   

3. The effect of VAV3 polymorphisms on thyroid cancer

   Background

   The incidence of thyroid cancer is rising rapidly in China, but there are few studies on the risk factors of thyroid cancer in the Chinese...

   Wanli Ren, Chongwen Xu, ... Yanxia Bai in Endocrine

   Article 22 July 2021

4. Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression

   Background

   Long noncoding RNAs (lncRNAs) are known to regulate tumorigenesis and cancer progression, but their contributions to non-small-cell lung...

   Zhenyao Chen, **n Chen, ... Zhaoxia Wang in Journal of Hematology & Oncology

   Article Open access 20 January 2020
   

5. Pregnancy induced hypertension and umbilical cord blood DNA methylation in newborns: an epigenome-wide DNA methylation study

   Objectivies

   Pregnancy induced hypertension (PIH) syndrome is a disease that unique to pregnant women and is associated with elevated risk of offspring...

   **aojun Zhu, Peiyue Jiang, ... **aofu Yang in BMC Pregnancy and Childbirth

   Article Open access 17 June 2024
   

6. MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer

   Gastric cancer (GC) is one of the most common malignant neoplasms. Invasion and metastasis are the main causes of GC-related deaths. Recently,...

   Ran-Ran Ma, Hui Zhang, ... Peng Gao in Oncogene

   Article 05 March 2021
   

7. Splenic proteome profiling in response to Marek’s disease virus strain GX0101 infection

   Marek’s disease virus (MDV) strain GX0101 was the first reported field strain of recombinant gallid herpesvirus type 2 (GaHV-2). However, the splenic...

   Chuan Wang, Yuanzi Liu, ... Zhao Zhang in BMC Veterinary Research

   Article Open access 05 January 2024
   

8. Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions

   Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in neuropsychiatric conditions. Emerging evidence indicates...

   Steven F. Grieco, Kevin G. Johnston, ... **angmin Xu in Molecular Psychiatry

   Article Open access 13 July 2023
   

9. The hub ten gene-based risk score system using RNA m⁶A methylation regulator features and tumor immune microenvironment in breast cancer

   Background

   RNA N ⁶ -methyladenosine (m ⁶ A) modification is primarily regulated by m ⁶ A regulators, which play significant epigenetic regulatory roles in...

   Baowen Yuan, Wei Liu, ... Hefen Yu in Breast Cancer

   Article 16 February 2022
   

10. Dietary anethole: a systematic review of its protective effects against metabolic syndrome

    Background

    Metabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe...

    Fatemeh Dehbashizadeh Torghabeh, Behjat Javadi, Amirhossein Sahebkar in Journal of Diabetes & Metabolic Disorders

    Article 27 December 2023
    

11. Barrett’s Esophagus: Who and How Do We Screen?

    Purpose of Review

    Barrett’s esophagus (BE) is the precursor of most Esophageal Adenocarcinomas (EACs) and progresses via the development of dysplasia....

    Bibek Saha, Anjul Verma, Prasad G. Iyer in Current Treatment Options in Gastroenterology

    Article 12 March 2024
    

12. Innovations in Screening Tools for Barrett’s Esophagus and Esophageal Adenocarcinoma

    Purpose of Review

    Esophageal adenocarcinoma (EAC) is a lethal disease with rapidly rising incidence. Screening for EAC and its metaplastic precursor,...

    Matthew G. Bell, Prasad G. Iyer in Current Gastroenterology Reports

    Article 15 October 2021
    

13. Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors

    The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory...

    Laura Clavaín, Isabel Fernández-Pisonero, ... Xosé R. Bustelo in Oncogene

    Article Open access 07 December 2022
    

14. Exploring the mechanism of fraxetin against acute myeloid leukemia through cell experiments and network pharmacology

    Objective

    Previous studies have shown that fraxetin has antitumor activity in a variety of tumors, but its role in acute myeloid leukemia (AML)...

    Tingting Fang, Lanqin Liu, Wenjun Liu in BMC Complementary Medicine and Therapies

    Article Open access 10 June 2024
    

15. Alterations of miR-16, miR-let-7a and their target genes expression in human blastocysts following vitrification and re-vitrification

    Embryo cryopreservation is a widely used technique in infertility management and today is an essential part of assisted reproductive technology...

    Maryam Daneshvar, Mansoureh Movahedin, ... Mehrdad Noruzinia in Reproductive Biology and Endocrinology

    Article Open access 09 October 2021
    

16. Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor

    The current paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho GTPases, can be a...

    L. Francisco Lorenzo-Martín, Sonia Rodríguez-Fdez, ... Xosé R. Bustelo in Oncogene

    Article 11 June 2020
    

17. Maternal periconceptional folic acid supplementation and risk for fetal congenital genitourinary system defects

    Background

    Taking folic acid supplementation could reduce the risk of neural tube defects for offspring in the maternal periconceptional period, but...

    Zixi Pang, Lei **, ... Lei ** in Pediatric Research

    Article 15 September 2023
    

18. Screening for Barrett’s Oesophagus: Are We Ready for it?

    Purpose of review

    The targeted approach adopted for Barrett’s oesophagus (BO) screening is sub-optimal considering the large proportion of BO cases...

    Aisha Yusuf, Rebecca C. Fitzgerald in Current Treatment Options in Gastroenterology

    Article Open access 16 March 2021
    

19. Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice

    Mouse behavioral genetic map** studies can identify genomic intervals modulating complex traits under well-controlled environmental conditions and...

    Kristin M. Mignogna, Zachary Tatom, ... Michael F. Miles in Neuropsychopharmacology

    Article Open access 29 June 2024
    

20. „Liquid biopsy“ in der gastrointestinalen Onkologie: Hype oder bald Realität?

    In the last 10 years, liquid biopsies in gastrointestinal cancer have received significant attention in science and research. New blood-based...

    Andreas W. Berger, Thomas Seufferlein in Journal für Gastroenterologische und Hepatologische Erkrankungen

    Article Open access 27 June 2022