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Being overweight worsens the relationship between urinary sodium excretion and albuminuria: the Wakuya study
Background/objectives(Micro)albuminuria (a manifestation of renal microvascular damage) is an independent predictor of mortality risk, even when the...
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Pseudo-nephropathy and hyper-excretion of urinary C-peptide: an overlooked adverse effect of an angiotensin receptor–neprilysin inhibitor (ARNI)
Sacubitril/valsartan, which is a combined angiotensin receptor–neprilysin inhibitor (ARNI), is used for the treatment of chronic heart failure and...
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Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension
BackgroundPregnancy involves major adaptations in renal haemodynamics, tubular, and endocrine functions. Hypertensive disorders of pregnancy are a...
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Effects of esaxerenone on blood pressure, urinary albumin excretion, serum levels of NT-proBNP, and quality of life in patients with primary aldosteronism
Primary aldosteronism (PA) is typically managed with mineralocorticoid receptor antagonists (MRAs) barring adrenalectomy. The efficacy of...
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Choroidal thickness in relation to urinary albumin excretion rate in type 2 diabetes mellitus without retinopathy
BackgroundTo evaluate choroidal thickness (CT) in diabetic patients without diabetic retinopathy (DR) in relation to the urinary albumin excretion...
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Association of urinary calcium excretion with chronic kidney disease in patients with type 2 diabetes
PurposeHerein, we investigated the correlation between urinary calcium excretion (UCaE) and chronic kidney disease (CKD) in patients with type 2...
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Urine albumin-to-creatinine ratio diurnal variation rate predicts outcomes in idiopathic membranous nephropathy
BackgroundIdiopathic membranous nephropathy (IMN) is a leading cause of end-stage renal disease (ESRD). The purpose of this study was to evaluate...
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Determinants on urinary excretion of oxalate and other key factors related to urolithiasis among patients with chronic kidney disease: a single center study
PurposeUrolithiasis is a known risk factor for chronic kidney disease (CKD). However, how CKD might affect the risk of incidence of urolithiasis is...
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Reference values for urinary protein, albumin, beta 2-microglobulin, and the alpha 1-microglobulin-to-creatinine ratio in Japanese children
BackgroundThe importance of the ratio of creatinine to urinary protein, albumin, and low-molecular weight protein as a urinary marker in chronic...
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Spot urinary sodium in CKD patients: correlation with 24h-excretion and evaluation of commonly used prediction equations
BackgroundSalt intake in CKD patients can affect cardiovascular risk and kidney disease progression. Twenty-four hour (24h) urine collections are...
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Mid-Trimester Spot Urinary Albumin/Creatinine Ratio as a Screening Tool in Prediction of Pre-eclampsia
Aims and ObjectivesTo determine utilization of spot urinary albumin/creatinine ratio (UACR) to predict subsequent development of preeclampsia,...
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Urinary free cortisol excretion is associated with lumbar bone density in patients with adrenal Cushing’s syndrome
Patients with adrenal Cushing’s syndrome have a poor prognosis due to the autonomous hypersecretion of endogenous cortisol from the adrenal gland....
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Association of albumin, globulin and albumin/globulin ratio with renal injury in type 2 diabetic nephropathy patients
BackgroundStudies have shown that albumin/globulin ratio (AGR) can assess the extent of kidney damage in type 2 diabetic nephropathy (T2DN). However,...
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Glomerular expression and urinary excretion of fatty acid-binding protein 4 in IgA nephropathy
BackgroundFatty acid-binding protein 4 (FABP4) is secreted from adipocytes and macrophages in adipose tissue and acts as an adipokine. It has...
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Optimal threshold of urinary albumin-to-creatinine ratio (UACR) for predicting long-term cardiovascular and noncardiovascular mortality
PurposeTraditional cutoff values of urinary albumin-to-creatinine ratio (UACR) for predicting mortality have recently been challenged. In this study,...
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Association between 1-year changes in urinary albumin-to-creatinine ratio and kidney disease progression in Japanese individuals with diabetes: a historical cohort study
BackgroundThe National Kidney Foundation recently proposed a ≥ 30% decrease in urinary albumin–to–creatinine ratio (UACR) over 0.5–2 years as a...
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The relationship between urinary albumin to creatinine ratio and all-cause mortality in the elderly population in the Chinese community: a 10-year follow-up study
BackgroundIn patients with diabetes and hypertension, proteinuria is independently associated with all-cause death. However, in the general...
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Exploratory study on the relationship between urinary sodium/potassium ratio, salt intake, and the antihypertensive effect of esaxerenone: the ENaK Study
Excessive salt intake is one of the causes of hypertension, and reducing salt intake is important for managing the risk of hypertension and...
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Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate
PurposeThe objectives of this study were to characterize the absorption, metabolism, and excretion of sotorasib and determine the metabolites present...
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Impact of urinary calcium excretion on kidney, bone, and cardiovascular systems in patients with bone biopsy proven osteoporosis: a longitudinal long-term follow-up study
SummaryThe impact of urine calcium on kidney, bone, and cardiovascular systems in osteoporosis is not well-known. In this 7-year-follow-up study,...
