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The Gut Microbiome Affects Atherosclerosis by Regulating Reverse Cholesterol Transport
The human system’s secret organ, the gut microbiome, has received considerable attention. Emerging research has yielded substantial scientific...
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The potential role of cholesterol in Parkinson’s disease neuropathology: perpetrator or victim
Parkinson’s disease (PD) is a neurodegenerative disease characterized by deposition of α-synuclein and aggregation of Lewy bodies. Cholesterol is...
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Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy
Aims/hypothesisHyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy,...
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The role of blood cholesterol quality in patients with advanced cancer receiving immune checkpoint inhibitors
IntroductionImmune checkpoint inhibitors (ICIs) became the standard of care for several solid tumors. A limited fraction of patients (pts) achieves a...
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Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia
Purpose of ReviewWe seek to establish whether high-density lipoprotein HDL metabolism and reverse cholesterol transport (RCT) impairment is an...
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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD),...
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Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats
BackgroundHypercholesterolemia is associated with tendon pathology, but the reasons underpinning this relationship are not well understood....
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Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann–Pick C1 Disease
BackgroundMutations in the NPC1 gene result in sequestration of unesterified cholesterol (UC) and glycosphingolipids in most tissues leading to...
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The TICE Pathway: Mechanisms and Potential Clinical Applications
Purpose of ReviewTransintestinal cholesterol excretion (TICE) is a non-biliary pathway that excretes excess cholesterol from the body through feces....
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Genetic variants in the adenosine triphosphate-binding cassette transporter A1 and risk of age-related macular degeneration
Genetic variants in ABCA1 are associated with higher concentrations of high-density lipoprotein (HDL) cholesterol. Higher HDL cholesterol...
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Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients
The metabolic effects induced by antipsychotics in vitro depend on their action on the trafficking and biosynthesis of sterols and lipids. Previous...
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Upregulation of NPC1 and its association with poor prognosis in gastric cancer
BackgroundThe Niemann–Pick disease type C1 (NPC1) protein plays a pivotal role in lipid transport, particularly free cholesterol, within...
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Clinical disease progression and biomarkers in Niemann–Pick disease type C: a prospective cohort study
BackgroundNiemann–Pick disease type C (NPC) is a rare, progressive, neurodegenerative disease associated with neurovisceral manifestations resulting...
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Characterization of lipoproteins and associated lipidome in very preterm infants: a pilot study
BackgroundPreterm birth is associated with higher risks of suboptimal neurodevelopment and cardiometabolic disease later in life. Altered...
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Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study
BackgroundAtherosclerotic vascular diseases are a leading global cause of morbidity and mortality. Dyslipidemia, a major modifiable risk factor for...
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Update on Sitosterolemia and Atherosclerosis
Purpose of ReviewThe purpose of this review was to summarize important and updated information on sitosterolemia. Sitosterolemia is an inherited...
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Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Chronic kidney disease (CKD) is a global health problem with rising incidence and prevalence. Among several pathogenetic mechanisms responsible for...
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Phenotypic expression of swallowing function in Niemann–Pick disease type C1
BackgroundNiemann–Pick disease type C1 (NPC1) is a rare autosomal recessive disease characterized by endolysosomal accumulation of unesterified...
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ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future
Purpose of ReviewThe elevated adverse cardiovascular event rate among patients with low high-density lipoprotein cholesterol (HDL-C) formed the basis...
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Glycemic variability leads to higher levels of auto-oxidized oxysterol species in patients with type 1 diabetes mellitus
PurposeHyperglycemia and glycemic variability (GV) are associated with oxidative stress in patients with diabetes mellitus (DM). Oxysterol species,...
