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Micromotion and stress shielding between taper fluted and cylindrical femoral stems for Paprosky bone deficiency type IIIB
PurposeTaper fluted and cylindrical femoral stems have been commonly used for revision surgery with femoral bone loss. Shape and material differences...
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Laparoscopic Resection of Perihilar Cholangiocarcinoma Type IIIb: A Video Demonstration of No-Touch En-Block Technique and Radical Lymphadenectomy
BackgroundMinimally invasive surgery for perihilar cholangiocarcinoma (pCCA) is in an exploratory phase by now and is only recommended for carefully...
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Monolateral external fixation versus internal fixation of Gustilo IIIB open tibial fractures: a multicenter comparative study
PurposeGustilo IIIB open tibial fractures are associated with significant risks of complications particularly nonunion and fracture-related...
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Comparison of Bismuth IIIa and IIIb Types of Hilar Cholangiocarcinoma: a Multi-center Case Series Analysis of China
The differences between Bismuth IIIa and IIIb types of hilar cholangiocarcinoma are unclear. Thus, this study aimed to compare the clinical...
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Type IIIb endoleak due to stent suture line fabric breakage in the Endurant stent graft: a case report
BackgroundEarly type IIIb endoleak is a very rare complication of endovascular aneurysm repair (EVAR).
Case presentationAn 87-year-old man was...
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High pre-chemoradiotherapy pan-immune-inflammation value levels predict worse outcomes in patients with stage IIIB/C non-small-cell lung cancer
Background and objectivesWe explored the prognostic usefulness of the pan-immune-inflammation value (PIV) in patients with stage IIIB/C...
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Intraoperative implantation of 125I seeds improves prognosis in refractory stage IIIB cervical cancer: a case report and literature review
BackgroundConcurrent chemoradiation is the standard treatment for advanced cervical cancer. However some patients still have a poor prognosis, and...
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Real-world clinical outcome and safety of adjuvant human Interferon-alpha1b in resected stage IIIB or IIIC melanoma: results of a retrospective study
BackgroundHuman interferon-α1b (hIFN-α1b) is the first genetically engineered drug approved by the National Medical Product Administration for cancer...
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Surgery for stage IIB–IIIB small cell lung cancer
PurposeThe NCCN guidelines do not recommend surgery for T3–4N0M0/T1–4N1–2M0 small cell lung cancer (SCLC) due to a lack of evidence.
Methods ...
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Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis
We describe herein the case of a 65-year-old patient on chronic hemodialysis with a medical history of idiopathic thrombocytopenia who experienced...
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Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine Versus Nimenrix in Healthy Adolescents: A Randomized Phase IIIb Multicenter Study
IntroductionMany immunization programs in Europe recommend quadrivalent meningococcal vaccinations, which are often administered concomitantly with...
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Efficacy and safety of **an-Lian-Jie-Du optimization decoction as an adjuvant treatment for prevention of recurrence in patients with stage IIIB/IIIC colon cancer: study protocol for a multicentre, randomized controlled trial
IntroductionColon cancer remains one of the most prevalent cancers worldwide. Unfortunately, there are no recognized and effective therapeutic...
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Robotic Resection of a Type IIIB Klatskin Tumor
Perihilar cholangiocarcinoma (Klatskin tumor) is one of the most challenging hepatobiliary cancers to treat due to its critical location and tendency...
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Limb salvage versus primary amputation in Gustilo–Anderson IIIB and IIIC tibial fractures: a systematic review and meta-analysis
IntroductionThe last systematic review on this topic was published in 2008. With advances in surgical techniques, patients with mangled extremities...
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Effects of traditional Chinese medicine collaborative model (TCMCM) combined with adjuvant chemotherapy on IIIb and IIIc gastric cancer: a protocol for a randomized controlled trial
BackgroundMetastasis and/or recurrence can decrease the survival time of gastric cancer patients undergoing radical operation. Among them, those with...
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Afatinib in Untreated Stage IIIB/IV Lung Adenocarcinoma with Major Uncommon Epidermal Growth Factor Receptor (EGFR) Mutations (G719X/L861Q/S768I): A Multicenter Observational Study in Taiwan
BackgroundReal-world clinical experience with afatinib as a treatment for advanced lung adenocarcinoma harboring uncommon epidermal growth factor...
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The trajectory of clinical responses in patients with early rheumatoid arthritis who achieve sustained remission in response to abatacept: subanalysis of AVERT-2, a randomized phase IIIb study
BackgroundAVERT-2 (a phase IIIb, two-stage study) evaluated abatacept + methotrexate versus methotrexate alone, in methotrexate-naive,...
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FGFR2-IIIb Expression by Immunohistochemistry Has High Specificity in Cholangiocarcinoma with FGFR2 Genomic Alterations
BackgroundFGFR2 genomic alterations are observed in 10–20% of cholangiocarcinoma (CCA). Although FGFR2 fusions are an important actionable target, FGFR2...
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Interim analysis of the efficiency and safety of neoadjuvant PD-1 inhibitor (sintilimab) combined with chemotherapy (nab-paclitaxel and carboplatin) in potentially resectable stage IIIA/IIIB non-small cell lung cancer: a single-arm, phase 2 trial
IntroductionWhile some clinical studies have shown that PD-1 and PD-L1 can also be an effective neoadjuvant treatment for early-stage non-small cell...
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A Phase IIIb Open-Label, Single-Arm Study of Afatinib in EGFR TKI-Naïve Patients with EGFRm+ NSCLC: Final Analysis, with a Focus on Patients Enrolled at Sites in China
BackgroundAfatinib has been shown as a suitable option for the treatment of epidermal growth factor receptor mutation-positive ( EGFR m+)...
