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Neurons cytoskeletal architecture remodeling during the replication cycle of mouse coronavirus MHV-JHM: a morphological in vitro study
Nowadays, the population is still struggling with a post-COVID19 syndrome known as long COVID, including a broad spectrum of neurological problems....
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Summary of the ISFP congress, Brussels, 10–12 November, 2022
The 7th International Congress of the ISFP was held in Brussels in November 2022. Hundreds of attendees from all over the world had the rare...
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Tumor-treating fields in cancer therapy: advances of cellular and molecular mechanisms
Tumor-Treating Fields (TTFields) use intermediate-frequency and low-intensity electric fields to inhibit tumor cells. However, their mechanisms are...
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Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP
Malignant pleural mesothelioma is a rare and aggressive neoplasm, which has primarily been attributed to the exposure to asbestos fibers (83% of...
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Understanding current experimental models of glioblastoma-brain microenvironment interactions
Glioblastoma (GBM) is a common and devastating primary brain tumor, with median survival of 16–18 months after diagnosis in the setting of...
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Patterns of neuronal Rhes as a novel hallmark of tauopathies
The farnesyltransferase inhibitor, Lonafarnib, reduces tau inclusions and associated atrophy in familial tauopathy models through activation of...
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An update to experimental and clinical aspects of tumor-associated macrophages in cancer development: hopes and pitfalls
Tumor-associated macrophages (TAMs) represent one of the most abundant tumor-infiltrating stromal cells, and their normal function in tumor...
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Extracellular Mitochondrial Dysfunction in Cerebrospinal Fluid of Patients with Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
BackgroundMitochondrial dysfunction is related to brain ischemic injury and neural cell death. However, little is known about the association between...
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Intercellular mitochondrial transfer as a means of tissue revitalization
As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion frequently undergoes morphological or positional changes when...
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Mitochondrial dysfunction: mechanisms and advances in therapy
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression....
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Extracellular Vesicles as Messengers in Atherosclerosis
Atherosclerosis is a major cause of cardiovascular diseases. Most cells involved in atherosclerosis can shed extracellular vesicles (EVs). Both...
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Exosomes in Allergic Airway Diseases
Purpose of ReviewThis review will cover what is known regarding exosomes and allergy, and furthermore discuss novel mechanism of exosome-mediated...
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Transmission of α-synuclein seeds in neurodegenerative disease: recent developments
Cell-to-cell transmission of proteopathic alpha-synuclein (α-syn) seeds is increasingly thought to underlie the progression of neurodegenerative...
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Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer
Cancer-associated fibroblasts (CAFs) are the major cellular stromal component of many solid tumors. In prostate cancer (PCa), CAFs establish a...
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Information handling by the brain: proposal of a new “paradigm” involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission
The current view on the organization of the central nervous system (CNS) is basically anchored to the paradigm describing the brain as formed by...
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KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2
The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by...
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NF-κB-mediated transcriptional upregulation of TNFAIP2 by the Epstein–Barr virus oncoprotein, LMP1, promotes cell motility in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC), which is closely associated with Epstein–Barr virus (EBV), is a metastasis-prone epithelial cancer. We previously...
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Volume transmission and its different forms in the central nervous system
Volume transmission (VT) is a widespread mode of intercellular communication that occurs in the extracellular fluid (ECF) and in the cerebrospinal...
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Paracrine induction of endothelium by tumor exosomes
Cancers use a nanoscale messenger system known as exosomes to communicate with surrounding tissues and immune cells. However, the functional...
