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Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration
Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) exhibit characteristic neuronal and glial inclusions of...
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Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy
Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National Institute of Neurological Disorders and Stroke (NINDS)...
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Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy
Microtubule-associated protein tau ( MAPT ) aggregates in neurons, astrocytes and oligodendrocytes in a number of neurodegenerative diseases, including...
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Tau immunotherapy is associated with glial responses in FTLD-tau
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologic subtypes of frontotemporal lobar degeneration with tau...
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS)....
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurodegenerative diseases as a...
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Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?
Olfactory impairments contribute to the psychopathology of mental illnesses such as schizophrenia and depression. Recent neuroscience research has...
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Multifaceted roles of APOE in Alzheimer disease
For the past three decades, apolipoprotein E ( APOE ) has been known as the single greatest genetic modulator of sporadic Alzheimer disease (AD) risk,...
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Endemic parkinsonism: clusters, biology and clinical features
The term ‘endemic parkinsonism’ refers to diseases that manifest with a dominant parkinsonian syndrome, which can be typical or atypical, and are...
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Latent trait modeling of tau neuropathology in progressive supranuclear palsy
Progressive supranuclear palsy (PSP) is the second most common neurodegenerative Parkinsonian disorder after Parkinson’s disease, and is...
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Pathomechanisms of depression in progressive supranuclear palsy
Depression is one of the most frequent neuropsychiatric symptoms in progressive supranuclear palsy (PSP), a four-repeat tauopathy and most common...
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Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography
PurposeAbnormal tau accumulation within the brain plays an important role in tauopathies such as Alzheimer’s disease and frontotemporal dementia....
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Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer’s disease, corticobasal degeneration and progressive supranuclear palsy brains
Recent mechanistic and structural studies have challenged the classical tauopathy classification approach and revealed the complexity and...
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as...
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Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by...
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Olfactory bulb anomalies in KBG syndrome mouse model and patients
ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We...
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Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
Intracellular accumulation of abnormal proteins with conformational changes is the defining neuropathological feature of neurodegenerative diseases....
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Cellular and regional vulnerability in frontotemporal tauopathies
The frontotemporal tauopathies all deposit abnormal tau protein aggregates, but often of only certain isoforms and in distinguishing pathologies of...
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In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and...
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α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease
α-Synuclein is a soluble protein that is present in abundance in the brain, though its normal function in the healthy brain is poorly defined....
