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Showing 1-10 of 10 results

  1. The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial

    Background

    The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human...

    Mervyn Singer, Antoni Torres, ... Tobias Welte in Critical Care
    Article Open access 09 November 2023

  2. Biochemical Characterization of a New 10% IVIG Preparation [IgG Next Generation (BT595)/Yimmugo®] Obtained from a Manufacturing Process Preserving IgA/IgM Potential of Human Plasma

    Background and Objective

    Human plasma is used for the generation of several life-saving drugs and contains valuable antibodies from the immunoglobulin...

    Christian Duellberg, Achim Hannappel, ... Oliver Maneg in Drugs in R&D
    Article Open access 19 July 2023

  3. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

    Purpose

    The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA,...

    Tobias Welte, R. Phillip Dellinger, ... Antoni Torres in Intensive Care Medicine
    Article Open access 09 April 2018

  4. Towards personalized medicine: a sco** review of immunotherapy in sepsis

    Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few proven therapies...

    Marleen A. Slim, Niels van Mourik, ... Lonneke A. van Vught in Critical Care
    Article Open access 28 May 2024

  5. Best-practice IgM- and IgA-enriched immunoglobulin use in patients with sepsis

    Background

    Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with...

    Axel Nierhaus, Giorgio Berlot, ... Massimo Girardis in Annals of Intensive Care
    Article Open access 07 October 2020

  7. Future of Therapy for Inborn Errors of Immunity

    Over the past 20 years, the rapid evolution in the diagnosis and treatment of primary immunodeficiencies (PI) and the recognition of immune...

    Elena Perez in Clinical Reviews in Allergy & Immunology
    Article 12 January 2022

  9. Intensivmedizinische Studien aus 2017/2018

    C. J. Reuß, M. Bernhard, ... T. Brenner in Der Anaesthesist
    Article 06 August 2018
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