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Randomized controlled trial of an app for cancer pain management
PurposeThe primary objective of this investigation was to devise a mobile application for self-management of cancer-related discomfort, with the...
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The Cure SMA Clinical Trial Experience Survey: A Study of Trial Participant Perspectives on Clinical Trial Management and Patient-Centric Management Practices
IntroductionUnderstanding clinical trial experiences can illuminate opportunities to optimize trial design and management, with potential benefits...
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Self-management including exercise, education and activity modification compared to usual care for adolescents with Osgood-Schlatter (the SOGOOD trial): protocol of a randomized controlled superiority trial
BackgroundOsgood-Schlatter is the most frequent growth-related injury affecting about 10% of physically active adolescents. It can cause long-term...
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Mean Arterial Pressure (MAP) Trial: study protocol for a multicentre, randomized, controlled trial to compare three different strategies of mean arterial pressure management during cardiopulmonary bypass
BackgroundOne of the main goals of cardiopulmonary bypass (CPB) is targeting an adequate mean arterial pressure (MAP) during heart surgery, in order...
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Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial
BackgroundHallux valgus is a common and disabling condition. This randomised pilot and feasibility trial aimed to determine the feasibility of...
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Development of an integrated and comprehensive clinical trial process management system
BackgroundThe process of initiating and completing clinical drug trials in hospital settings is highly complex, with numerous institutional,...
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Optimising diagnosis and management of kidney disease: an implementation trial of a clinical decision support system future health today
BackgroundChronic kidney disease affects more than 10% of the world’s population and is a non-communicable disease of global concern and priority....
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Summary of clinical investigation plan for The DIATEC trial: in-hospital diabetes management by a diabetes team and continuous glucose monitoring or point of care glucose testing – a randomised controlled trial
BackgroundWorldwide, up to 20 % of hospitalised patients have diabetes mellitus. In-hospital dysglycaemia increases patient mortality, morbidity, and...
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Non-nutritive sweetened beverages versus water after a 52-week weight management programme: a randomised controlled trial
Background/objectiveSugar-sweetened beverages are a substantial source of dietary sugar that can contribute to weight gain and the risk of type 2...
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ReActiv8 Stimulation Therapy vs. Optimal Medical Management: A Randomized Controlled Trial for the Treatment of Intractable Mechanical Chronic Low Back Pain (RESTORE Trial Protocol)
IntroductionChronic low back pain (CLBP) is the leading cause of years lived with disability globally. The role of restorative neurostimulation in...
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Effectiveness of DialBetesPlus, a self-management support system for diabetic kidney disease: Randomized controlled trial
We evaluated the effectiveness of a mobile health (mHealth) intervention for diabetic kidney disease patients by conducting a 12-month randomized...
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The Gestational Obesity Weight Management: Implementation of National Guidelines (GLOWING) study: a pilot cluster randomised controlled trial
BackgroundPregnancy weight management interventions can improve maternal diet, physical activity, gestational weight gain, and postnatal weight...
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Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial
BackgroundChronic pancreatitis (CP) is an inflammatory disease that may be complicated by abdominal pain, pancreatic dysfunction, nutritional...
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Development of a multidisciplinary medication management program in nursing homes: protocol for a randomized controlled trial
BackgroundPolypharmacy and the use of potentially inappropriate medications are common among nursing home residents and are associated with negative...
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Telemedicine management of obstructive sleep apnea disorder in China: a randomized, controlled, non-inferiority trial
PurposePrevious studies assessed different components of telemedicine management pathway for OSA instead of the whole pathway. This randomized,...
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A simulation training of family management for parents of children with epilepsy: a randomized clinical trial
BackgroundEpilepsy is a chronic neurological disorder that is more likely to be diagnosed in children. The main treatment involves long-term use of...
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Study protocol for the management of impacted maxillary central incisors: a multicentre randomised clinical trial: the iMAC Trial
BackgroundFailure of eruption of the maxillary permanent incisor teeth usually presents in the mixed dentition between the ages of 7 and 9 years....
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Pilot randomized controlled trial of restricted versus liberal crystalloid fluid management in pediatric post-operative and trauma patients
BackgroundIntravenous (IV) fluid therapy is essential in the treatment of critically ill pediatric surgery and trauma patients. Recent studies have...
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Application of the patient-reported outcome-based postoperative symptom management model in lung cancer: a multicenter randomized controlled trial protocol
IntroductionLung cancer is the most common cancer in China, with the highest mortality rate. Surgery is the primary treatment for early lung cancer....
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Community-based management of a five-arm randomised clinical trial in COVID-19 outpatients in South Africa: challenges and opportunities
BackgroundRepeated COVID-19 waves and corresponding mitigation measures have impacted health systems globally with exceptional challenges. In...
