Search
Search Results
-
Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining...
-
Intestinal metabolites predict treatment resistance of patients with depression and anxiety
BackgroundThe impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on...
-
A multiparameter liquid biopsy approach allows to track melanoma dynamics and identify early treatment resistance
Melanoma heterogeneity is a hurdle in metastatic disease management. Although the advent of targeted therapy has significantly improved patient...
-
A perspective on tumor radiation resistance following high-LET radiation treatment
High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to...
-
Association between HIV and acquisition of rifamycin resistance with first-line TB treatment: a systematic review and meta-analysis
BackgroundMulti-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important public health concern, including in settings with high HIV...
-
Genotype-stratified treatment for monogenic insulin resistance: a systematic review
BackgroundMonogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of...
-
Factors determining resistance to conventional disease-modifying anti-rheumatic drug treatment in oligoarticular juvenile idiopathic arthritis
ObjectiveOur study was designed to investigate the reasons for starting the conventional disease-modifying anti-rheumatic drugs (DMARDs) and the...
-
Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil
BackgroundSince January 2017, the recommended first-line antiretroviral regimen in Brazil is the fixed-dose combination of tenofovir plus lamivudine...
-
High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in Austria
BackgroundMycoplasma genitalium (MG) is an emerging sexually transmitted infection, often harboring resistance-associated mutations to azithromycin...
-
Antibiotics for Treatment of Chronic Periodontitis, in Conditions of Increased Resistance
The study is oriented around the collection of already published data about treatment of chronic periodontitis according to specifics with or without...
-
A Multicenter, Open-Label, Single-Arm Trial of the Efficacy and Safety of Empagliflozin Treatment for Refractory Diabetes Mellitus with Insulin Resistance (EMPIRE-01)
IntroductionInsulin resistance syndrome and lipoatrophic diabetes are characterized by severe insulin resistance and are often refractory to...
-
Oral Faropenem Sodium — Implications for Antimicrobial Resistance and Treatment Effectiveness
Rising antimicrobial resistance (AMR) is causing therapeutic failures with antibiotics. Inappropriate use is a contributing factor. One such...
-
Increasing multidrug resistance in leech borne infections. Should we adjust antibiotic treatment regime in plastic surgery? A systematic review
BackgroundA growing number of reports of serious wound infections during medical leech therapy over the last decades caused by the leech gut symbiont
-
Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis
BackgroundThe World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57%...
-
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance
The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between...
-
Bedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study
BackgroundBedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype...
-
High prevalence of pre-treatment HIV drug resistance in Papua New Guinea: findings from the first nationally representative pre-treatment HIV drug resistance study
BackgroundDetermining the prevalence of pre-treatment HIV drug resistance (PDR) is important to assess the effectiveness of first-line therapies. To...
-
Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
PurposeCisplatin is the core chemotherapeutic drug used for first-line treatment of advanced non-small cell lung cancer (NSCLC). However, drug...
-
Supervised resistance exercise for women with ovarian cancer who have completed first-line treatment: a pragmatic study
ObjectivesIn ovarian cancer (OC), suboptimal muscle morphology (i.e., low muscle mass and density) is associated with poor clinical outcomes, yet...
-
Janus kinase inhibitor overcomes resistance to immune checkpoint inhibitor treatment in peritoneal dissemination of gastric cancer in C57BL/6 J mice
BackgroundCancer immunotherapy aims to unleash the immune system’s potential against cancer cells, providing sustained relief for tumors responsive...
