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Using the ‘Leapfrog’ Design as a Simple Form of Adaptive Platform Trial to Develop, Test, and Implement Treatment Personalization Methods in Routine Practice
The route for the development, evaluation and dissemination of personalized psychological therapies is complex and challenging. In particular, the...
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Understanding Patient Experiences to Inform Future Studies to Optimize Personalization of Treatment for Early Breast Cancer
BackgroundBreast cancer treatment is multimodal, but not all patients benefit from each treatment, and many experience morbidities significantly...
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Transcranial magnetic stimulation treatment in Alzheimer’s disease: a meta-analysis of its efficacy as a function of protocol characteristics and degree of personalization
Alzheimer’s disease (AD) represents the most common type of neurodegenerative disorder. Although our knowledge on the causes of AD remains limited...
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Alert-Grou**: Smart Personalization of Monitoring System Thresholds to Help Healthcare Teams Struggle with Alarm Fatigue in Intensive Care
In Intensive Care Units (ICUs), patients are monitored using various devices that generate alerts when specific metrics, such as heart rate and...
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A plea for personalization of the hemodynamic management of septic shock
Although guidelines provide excellent expert guidance for managing patients with septic shock, they leave room for personalization according to...
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Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials
Prostate cancer is the most frequent cancer in men and a leading cause of cancer death. Determining a patient’s optimal therapy is a challenge, where...
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Personalization in Gynecologic Oncology
This book thoroughly illustrates the designed and tailored medical approaches for tumors of the female reproductive organ. The chapters explore...
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Automated personalization of biomechanical knee model
PurposePatient-specific biomechanical models of the knee joint can effectively aid in understanding the reasons for pathologies and improve...
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Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment...
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Personalization of renal replacement therapy initiation: a secondary analysis of the AKIKI and IDEAL-ICU trials
BackgroundTrials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed...
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Treatment personalization in gastrointestinal neuroendocrine tumors
The clinical scenario of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is continuously changing due to significant improvements in the...
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Personalization of 99mTc-sestamibi activity in SPECT/CT myocardial perfusion imaging with the cardiofocal SmartZoom® collimator
BackgroundPatient radioprotection in myocardial perfusion imaging (MPI)-SPECT is important but difficult to optimize. The aim of this study was to...
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Leveraging Single-Case Experimental Designs to Promote Personalized Psychological Treatment: Step-by-Step Implementation Protocol with Stakeholder Involvement of an Outpatient Clinic for Personalized Psychotherapy
Our objective is to implement a single-case experimental design (SCED) infrastructure in combination with experience-sampling methods (ESM) into the...
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The PerPAIN trial: a pilot randomized controlled trial of personalized treatment allocation for chronic musculoskeletal pain—a protocol
BackgroundThe therapy of chronic musculoskeletal pain (CMSP) is complex and the treatment results are often insufficient despite numerous therapeutic...
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Tools to implement measurement-based care (MBC) in the treatment of opioid use disorder (OUD): toward a consensus
BackgroundThe prevalence and associated overdose death rates from opioid use disorder (OUD) have dramatically increased in the last decade. Despite...
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Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1): a phase I trial towards adaptive, image-controlled treatment delivery
PurposeTransarterial radioembolization (TARE) is a treatment for liver tumours based on injection of radioactive microspheres in the hepatic arterial...
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Adherence to Hidradenitis Suppurativa Treatment
Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that requires multimodal treatment. Adherence remains a significant challenge...
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Leveraging Measurement-Based Care to Reduce Mental Health Treatment Disparities for Populations of Color
Disparities in mental health treatment have consistently been documented for clients of color as compared to White clients. Most mental health care...
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Modern approach to resistant acromegaly
BackgroundTargets of acromegaly treatment are normalization of biochemical values, removal/reduction/stabilization of the pituitary mass, control of...
