Search
Search Results
-
Nuclear transport proteins: structure, function, and disease relevance
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental...
-
Role of miRNAs in macrophage-mediated kidney injury
Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles....
-
Investigating the potential mechanism of quercetin against cervical cancer
BackgroundCervical cancer is emerging as a potential target of increased susceptibility to coronavirus disease-2019 (COVID-19), leading to...
-
Targeting nuclear import and export in hematological malignancies
The transport of proteins across the nuclear membrane is a highly regulated process, essential for the cell function. This transport is actively...
-
An introduction to dynamic nucleoporins in Leishmania species: Novel targets for tropical-therapeutics
As an ailment, leishmaniasis is still an incessant challenge in neglected tropical diseases and neglected infections of poverty worldwide. At...
-
Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer
Diffuse-type gastric cancer (DGC) is a highly invasive subtype of gastric adenocarcinoma that frequently exhibits scattered peritoneal metastasis....
-
Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
Clinical observations suggest that the prevalence of autoimmune diseases is changing over time. Both autoimmune liver diseases and multiple sclerosis...
-
Nuclear pore complexes — a doorway to neural injury in neurodegeneration
The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative diseases are increasingly well defined, but the cellular...
-
Liquid–liquid phase separation in human health and diseases
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of...
-
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron degeneration and associated with aggregation of nuclear...
-
Liquid–liquid phase separation in tumor biology
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS...
-
ADARs, RNA editing and more in hematological malignancies
Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA...
-
Abnormal expression of rno_circRNA_014900 and rno_circRNA_005442 induced by ketamine in the rat hippocampus
BackgroundRecent studies have shown that circular RNA (circRNA) is rich in microRNA (miRNA) binding sites. We have previously demonstrated that the...
-
Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology
Insoluble aggregates containing TDP-43 are widely observed in the diseased brain, and defined as “TDP-43 pathology” in a spectrum of...
-
Effect of Keratinocytes on Myofibroblasts in Hypertrophic Scars
Myofibroblasts play a central role in matrix formation and wound contraction during wound healing and undergo apoptosis at the end of the healing....
-
Development of disease-modifying drugs for frontotemporal dementia spectrum disorders
Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes characterized by progressive executive, behavioural and language...
-
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis
Dysregulated RNA metabolism is emerging as a crucially important mechanism underpinning the pathogenesis of frontotemporal dementia (FTD) and the...
-
Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules
To enhance understanding of polycystic ovary syndrome (PCOS) at the molecular level; this investigation intends to examine the genes and pathways...
-
Rheumatology training and research in Iran
Rheumatology is one of the most important clinical subspecialties in Iran. In the past 2 decades, Iran has witnessed an immense progress in the field...
-
Genetics and epigenetics in the pathogenesis of primary biliary cholangitis
Primary biliary cholangitis (PBC) is a chronic, slowly progressive cholestatic autoimmune liver disease predominantly afflicting women. PBC is...