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Optimized scaling of translational factors in oncology: from xenografts to RECIST
PurposeTumor growth inhibition (TGI) models are regularly used to quantify the PK–PD relationship between drug concentration and in vivo efficacy in...
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15 years Ludwig Boltzmann Institute for Hematology and Oncology (LBI HO): achievements and future perspectives
Cancer stem cells, also known as leukemic stem cells (LSC) in the context of leukemias, are an emerging topic in translational oncology and...
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Utility and impact of quantitative pharmacology on dose selection and clinical development of immuno-oncology therapy
Immuno-oncology (IO) therapies have changed the cancer treatment landscape. Immune checkpoint inhibitors (ICIs) have improved overall survival in...
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A translational model-based approach to inform the choice of the dose in phase 1 oncology trials: the case study of erdafitinib
PurposeErdafitinib (JNJ-42756493, BALVERSA) is a tyrosine kinase inhibitor indicated for the treatment of advanced urothelial carcinoma. In this...
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Medical oncology workload, workforce census, and needs in Spain: two nationwide studies by the Spanish Society of medical oncology
PurposeGrowing complexity and demand for cancer care entail increased challenges for Medical Oncology (MO). The Spanish Society of Medical Oncology...
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Retrospective Assessment of Translational Pharmacokinetic–Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor
Background and ObjectivesDespite significant progress in biomedical research, the rate of success in oncology drug development remains inferior to...
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Translation of AI into oncology clinical practice
Artificial intelligence (AI) is a transformative technology that is capturing popular imagination and can revolutionize biomedicine. AI and machine...
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Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods
Cardio-oncology is an emerging interdisciplinary field dedicated to the early detection and treatment of adverse cardiovascular events associated...
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Disparities in Neuro-Oncology
Purposeof ReviewHealth disparities are preventable differences in the diagnosis, treatment, and outcomes of many diseases, including central nervous...
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Molecular tumour boards — current and future considerations for precision oncology
Over the past 15 years, rapid progress has been made in developmental therapeutics, especially regarding the use of matched targeted therapies...
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Humanized mouse models for immuno-oncology research
Immunotherapy has emerged as a promising treatment paradigm for many malignancies and is transforming the drug development landscape. Although...
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Perceptions of Readiness for Practice After Complex General Surgical Oncology Fellowship: A Survey Study
BackgroundSurgical subspecialty training aims to meet the needs of practicing surgeons and their communities. This study investigates career...
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Immune Checkpoint Inhibitors in Geriatric Oncology
Purpose of ReviewThis manuscript will update prior reviews of immune checkpoint inhibitors (ICIs) in light of basic science, translational, and...
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Functional precision oncology using patient-derived assays: bridging genotype and phenotype
Genomics-based precision medicine has revolutionized oncology but also has inherent limitations. Functional precision oncology is emerging as a...
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Biomarkers and translational research approaches in breast cancer—an update
Diagnosis and decision-making in the treatment of breast cancer patients is vastly dependent on the exploration of biomarkers. Estrogen receptor,...
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Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism
Purpose of ReviewThe article aims to investigate the complex relationship between cancer and cardiovascular disease (CVD), with a focus on the...
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CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is essentially an adaptive immunity weapon in...
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Are Sodium-Glucose Cotransporter-2 Inhibitors the Cherry on Top of Cardio-Oncology Care?
The increasing aging of the population combined with improvements in cancer detection and care has significantly improved the survival and quality of...
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Tumor immunology meets oncology (TIMO) XVII, April 20–22 2023 in Halle/Saale, Germany
During the TIMO meeting 2023, national and international scientists as well as clinicians gave novel insights as well as perspectives into basic and...