Search
Search Results
-
RUNX transcription factors: biological functions and implications in cancer
Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes....
-
Targeting PEA3 transcription factors to mitigate small cell lung cancer progression
Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination...
-
Effect of strontium on transcription factors identified by transcriptome analyses of bovine ruminal epithelial cells
BackgroundStrontium (Sr) has similar physicochemical properties as calcium (Ca) and is often used to evaluate the absorption of this mineral. Because...
-
Runt-related transcription factors in human carcinogenesis: a friend or foe?
PurposeCancer is one of the deadliest pathologies with more than 19 million new cases and 10 million cancer-related deaths across the globe. Despite...
-
Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases
Purpose of ReviewRunt-related transcription factors (RUNX) play critical roles in skeletal development, metabolism, and diseases. In mammals, three...
-
Role of Transcription Factors in the Management of Preterm Birth: Impact on Future Treatment Strategies
Preterm birth is defined as the birth of a neonate before 37 weeks of gestation and is considered as a leading cause of the under five deaths of...
-
Gene expression and transcriptional regulation driven by transcription factors involved in congenital heart defects
BackgroundCongenital heart disease (CHD) is one of the most important birth defects caused by more than one mutated gene. Mutations in the genes...
-
Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats
Chronic morphine administration alters gene expression in different brain regions, an effect which may contribute to plastic changes associated with...
-
Identification of the hub susceptibility genes and related common transcription factors in the skeletal muscle of Type 2 Diabetes Mellitus
BackgroundType 2 diabetes mellitus (T2DM) and its related complications contribute to the high morbidity and mortality in worldwide. Skeletal muscle...
-
De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors
BackgroundBenign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO...
-
Prognostic analysis of E2F transcription factors E2F1 and E2F3 in four independent pediatric neuroblastoma cohorts
BackgroundPreviously, we had analyzed the prognosis of E2F transcription factors across adult tumor types. However, the expressions and prognosis of...
-
Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens
Repeated cocaine use induces coordinated changes in gene expression that drive plasticity in the nucleus accumbens (NAc), an important component of...
-
Effect of hydroalcoholic seed extract of Nigella sativa on hepatic and pancreatic factors of Nrf2 and FGF21 in the regulation of insulin transcription factors of MafA and PDX-1 in streptozotocin-treated diabetic rats
IntroductionNigella sativa ( N. sativa ), one of the most commonly used medicinal herbs with antioxidant properties, increases blood insulin levels...
-
Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC) is the leading cause of death in all countries alike. In the current study, we have found out that Histone...
-
The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells
PurposeMembers of the AP-1 family of transcription factors are immediate early genes being modulated by different extracellular signals. The aim of...
-
A zinc finger transcription factor enables social behaviors while controlling transposable elements and immune response in prefrontal cortex
The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function...
-
Construction and validation of a transcription factors-based prognostic signature for ovarian cancer
BackgroundOvarian cancer (OC) is one of the most common and lethal malignant tumors worldwide and the prognosis of OC remains unsatisfactory....
-
A novel transcription factor SIPA1: identification and verification in triple-negative breast cancer
Transcription factors (TFs) regulate the expression of genes responsible for cell growth, differentiation, and responses to environmental factors. In...
-
Transcription factors linked to the molecular signatures in the development of hepatocellular carcinoma on a cirrhotic background
Mechanisms underlying the regulation of gene expression in cancer have been surveyed for decades to find novel prognostic factors and new targets for...
