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A zinc finger transcription factor enables social behaviors while controlling transposable elements and immune response in prefrontal cortex
The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function...
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Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
BackgroundPancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside (ASP) is an...
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Targeting PEA3 transcription factors to mitigate small cell lung cancer progression
Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination...
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Towards a scalable approach to assess speech organization across the psychosis-spectrum -online assessment in conjunction with automated transcription and extraction of speech measures
Automatically extracted measures of speech constitute a promising marker of psychosis as disorganized speech is associated with psychotic symptoms...
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ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma
Lung adenocarcinoma is a malignant tumor with high morbidity and mortality. ZBTB16 plays a double role in various tumors; however, the potential...
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Current understanding of ELF4 deficiency: a novel inborn error of immunity
BackgroundELF4 deficiency has been recently recognized as a novel disorder within the spectrum of inborn errors of immunity (IEIs), specifically...
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Measuring and controlling medical record abstraction (MRA) error rates in an observational study
BackgroundStudies have shown that data collection by medical record abstraction (MRA) is a significant source of error in clinical research studies...
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Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast cancer
BackgroundSex-determining region Y-box 3 (SOX3) protein, a SOX transcriptions factors group, has been identified as a key regulator in several...
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Occurrence and types of medication error and its associated factors in a reference teaching hospital in northeastern Iran: a retrospective study of medical records
BackgroundMedication errors are categorized among the most common medical errors that may lead to irreparable damages to patients and impose huge...
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Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer
CUB domain-containing protein 1 (CDCP1), a transmembrane protein with tumor pro-metastatic activity, is highly expressed in late-stage and...
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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma
Background. Uterine leiomyosarcoma is a rare aggressive smooth muscle cancer with poor survival rates. RNA Polymerase I (Pol I) activity is elevated...
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Study on the role of transcription factor SPI1 in the development of glioma
BackgroundGlioma is a common malignant brain tumor. The purpose of this study was to investigate the role of the transcription factor SPI1 in glioma.
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Portulaca oleracea L seed extracts counteract diabetic nephropathy through SDF-1/IL10/PPARγ–mediated tuning of keap1/Nrf2 and NF-κB transcription in Sprague Dawley rats
Background & objective: While oxidative stress is the key player driving diabetic nephropathy (DN), firm glycemic control remains the pillar...
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MicroRNA-92a-3p Inhibits Cell Proliferation and Invasion by Regulating the Transcription Factor 21/Steroidogenic Factor 1 Axis in Endometriosis
Endometriosis (EMS) is an estrogen-dependent disease. However, little is known about the regulation of estrogen, a potential therapeutic target, in...
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Unravelling roles of error-prone DNA polymerases in sha** cancer genomes
Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse underlying mutagenic mechanisms that shape cancer genomes...
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A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes
Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility, but its diagnosis biomarkers with high sensitivity and...
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PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1
The establishment of cell type specific gene expression by transcription factors and their epigenetic cofactors is central for cell fate decisions....
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Transcription factors linked to the molecular signatures in the development of hepatocellular carcinoma on a cirrhotic background
Mechanisms underlying the regulation of gene expression in cancer have been surveyed for decades to find novel prognostic factors and new targets for...
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Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia
The transcription factors PAX5, IKZF1, and EBF1 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that compound...
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Radiology Dictation Errors with COVID-19 Protective Equipment: Does Wearing a Surgical Mask Increase the Dictation Error Rate?
Our aim was to determine the effect of wearing a surgical mask on the number and type of dictation errors in unedited radiology reports. IRB review...
