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Co-crystal of Tramadol-Celecoxib Versus Tramadol or Placebo for Acute Moderate-to-Severe Pain After Oral Surgery: Randomized, Double-Blind, Phase 3 Trial (STARDOM1)
IntroductionCo-crystal of tramadol-celecoxib (CTC) is the first analgesic co-crystal for acute pain. This completed phase 3 multicenter, double-blind...
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Comparison between the effects of epidural lidocaine, tramadol, and lidocaine–tramadol on postoperative pain in cats undergoing elective orchiectomy
BackgroundIn veterinary clinical practice, orchiectomy is one of the most common surgical procedures for cats and is performed mainly in young...
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Comparative safety of tramadol and other opioids following total hip and knee arthroplasty
BackgroundTramadol is increasingly used to treat acute postoperative pain among older adults following total hip and knee arthroplasty (THA/TKA)....
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Degenerative brain changes associated with tramadol use: an optical coherence tomography study
BackgroundTramadol—a synthetic opioid originally used as an analgesic—has been widely misused as an addictive drug in the middle east in the last...
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Clinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study
Background and ObjectivesTramadol is a centrally acting analgesic with a lower risk of addiction compared to opioids. Tramadol overdose is becoming a...
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Phase III study of bilayer sustained-release tramadol tablets in patients with cancer pain: a double-blind parallel-group, non-inferiority study with immediate-release tramadol capsules as an active comparator
PurposeWe investigated whether twice-daily administration of a bilayer tablet formulation of tramadol (35% immediate-release [IR] and 65%...
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The frequency and impact of tramadol addiction on acute aneurysmal subarachnoid hemorrhage: cross-sectional multicenter study
BackgroundArterial hypertension, cigarette smoking, excessive alcohol abuse and drug addiction such as cocaine all are known risk factors for...
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Efficacy and safety of parenteral and local application of tramadol in mandibular third molar extraction: a qualitative systematic review of current evidence
PurposeTo assess the efficacy and safety of perioperative parenteral administration or submucosal infiltration of tramadol for perioperative pain...
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The possible protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on tramadol-induced testicular damage in rats
BackgroundTramadol provokes oxidative stress that gives rise to apoptosis with alterations in the cellular structure and adversely influences male...
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Assessment of renal function indexes in methamphetamine or tramadol intoxication adults to the emergency departments: a systematic review and meta-analysis
BackgroundRenal dysfunction is one of the adverse effects observed in methamphetamine (MET) or tramadol abusers. In this study, we aimed to review...
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Multiple suicide attempts associated with addiction to tramadol
BackgroundThe opioid tramadol is used as analgesic drug, and more recently was also proposed for the management of major depressive disorder....
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Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials
Background and ObjectivesNew acute pain medications are needed that provide effective analgesia while minimizing side effects and opioid exposure....
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Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial
BackgroundCatheter-related bladder discomfort (CRBD is a painful complication of intraoperative urinary catheterization after anaesthesia. We...
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Tramadol for chronic pain in adults: protocol for a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
BackgroundChronic pain in adults is a frequent clinical symptom with a significant impact on patient well-being. Therefore, sufficient pain...
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Association between male sex hormones and tramadol abuse
BackgroundTramadol dependence is prevalent across Egypt. The allegation that it can improve sexual function is the main reason for its popularity...