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Population pharmacokinetics and toxicity correlation analysis of free and liposome-encapsulated doxorubicin in Chinese patients with advanced breast cancer
PurposeThe objective of this study was to investigate the pharmacokinetic characteristics of pegylated liposomal doxorubicin (PLD) in Chinese female...
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Cardiovascular toxicity of checkpoint inhibitors: review of associated toxicity and design of the Spanish Immunotherapy Registry of Cardiovascular Toxicity
Immune checkpoint inhibitors (ICI) have changed the prognosis of many tumors. However, concerning associated cardiotoxicity has been reported. Little...
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Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis
ObjectiveWe aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in...
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Cinnamon nanoemulsion mitigates acetamiprid-induced hepatic and renal toxicity in rats: biochemical, histopathological, immunohistochemical, and molecular docking analysis
Acetamiprid (ACDP) is a widely used neonicotinoid insecticide that is popular for its efficacy in controlling fleas in domestic settings and for...
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Forensic Implications of Kratom: Kratom Toxicity, Correlation with Mitragynine Concentrations, and Polypharmacy
Purpose of ReviewKratom, a preparation of the leaves collected from the Southeast Asian plant Mitragyna speciosa , has increased in use within the...
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Comprehensive geriatric assessment predicts radiation-induced acute toxicity in prostate cancer patients
PurposeThe purpose of the present prospective study was to evaluate the significance of geriatric conditions measured by a comprehensive geriatric...
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Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study
BackgroundCheckpoint inhibition has emerged as an effective treatment strategy for a variety of cancers, including in older adults. However, older...
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Body composition measures as a determinant of Alpelisib related toxicity
BackgroundBody composition has emerged as an important prognostic factor in patients treated with cancer. Severe depletion of skeletal muscle,...
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The interaction of financial toxicity and social support on social functioning in post-chemotherapy breast cancer patients: a cross-sectional study
PurposeTo explore the correlation between financial toxicity, social support, and social functioning in post-chemotherapy breast cancer patients, as...
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Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
BackgroundImmune checkpoint inhibitors (ICIs) have particular, immune-related adverse events (irAEs), as a consequence of interfering with...
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The impact of humanitarian aid on financial toxicity among cancer patients in Northwest Syria
IntroductionThe ongoing crisis in Syria has divided the country, leading to significant deterioration of the healthcare infrastructure and leaving...
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Toxicity burden patterns of MET-selective tyrosine kinase inhibitors: evidence from real-world pharmacovigilance
MET exon 14 skip** alterations and MET amplifications are recognized as oncogenic and targetable genetic changes in cancer patients. The treatment...
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Effectiveness and toxicity of five-fraction prone accelerated partial breast irradiation
PurposeOur institution was an early adopter of 5-fraction accelerated partial breast irradiation (ABPI) to treat women with early-stage breast...
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Financial toxicity following surgical treatment for colorectal cancer: a cross-sectional study
PurposeFinancial toxicity has become a global public health issue. The purpose of the study is to investigate and analyze the influencing factors of...
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Association of frailty with chemotherapy toxicity in chemotherapy-naive older patients with cancer
ObjectiveThe purpose of this study is to assess the relationship between chemotherapy toxicity and frailty as determined using the Edmonton Frail...
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Greater financial toxicity correlates with increased psychological distress and lower quality of life among Turkish cancer patients
PurposeThis study aims to investigate the factors that influence financial toxicity and its effects on both quality of life and psychological...
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A prediction model for severe hematological toxicity of BTK inhibitors
Bruton’s tyrosine kinase inhibitor (BTKi) has revolutionized the treatment of B-cell lymphomas. However, BTKi-related hematological toxicity hinders...
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Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A combination of drugs is...
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Association between financial toxicity and health-related quality of life of patients with gynecologic cancer
ObjectivesPatients often struggle with their financial situation during cancer treatment due to treatment-related costs or loss of income. This...
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Quantitative assessments of late radiation-induced skin and soft tissue toxicity and correlation with RTOG scales and biological equivalent dose in breast cancer
PurposeRadiation-induced toxicity (RIT) is usually assessed by inspection and palpation. Due to their subjective and unquantitative nature, objective...
