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Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer
BackgroundPeritoneal dissemination is the predominant feature of malignant progression in ovarian cancer and is a major cause of poor surgical...
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MRI-based radiomics feature combined with tumor markers to predict TN staging of rectal cancer
The aim of this study is to evaluate the predictive ability of MRI-based radiomics combined with tumor markers for TN staging in patients with rectal...
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Sialyl-Tn serves as a potential therapeutic target for ovarian cancer
BackgroundOvarian cancer remains the deadliest of the gynecologic cancers in the United States. There have been limited advances in treatment...
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Prostate-specific membrane antigen radioguided surgery with negative histopathology: an in-depth analysis
PurposeTo identify reasons for negative histopathology of specimens from prostate-specific membrane antigen (PSMA) radioguided surgery (PSMA-RGS) in...
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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?
Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA)...
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Fipronil disturbs the antigen-specific immune responses and GABAergic gene expression in the ovalbumin-immunized BALB/c mice
BackgroundFipronil (FPN) is a broad-spectrum pesticide and commonly known as low toxicity to vertebrates. However, increasing evidence suggests that...
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The challenge of selecting tumor antigens for chimeric antigen receptor T-cell therapy in ovarian cancer
Ovarian cancer (OC) is one of the most common cancers in women, with a high mortality rate and very few available and effective treatments. Evidence...
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Current approaches to develop “off-the-shelf” chimeric antigen receptor (CAR)-T cells for cancer treatment: a systematic review
Chimeric antigen receptor (CAR)-T cell therapy is one of the most promising advances in cancer treatment. It is based on genetically modified T cells...
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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
BackgroundImmunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness of chimeric...
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Oxygen regulates ILC3 antigen presentation potential and pregnancy-related hormone actions
Early pregnancy is marked by placentation and embryogenesis, which take place under physiological low oxygen concentrations. This oxygen condition is...
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CD19/BAFF-R dual-targeted CAR T cells for the treatment of mixed antigen-negative variants of acute lymphoblastic leukemia
Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent antitumor effects in B-cell malignancies including acute lymphoblastic leukemia...
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Allogeneic Chimeric Antigen Receptor Therapy in Lymphoma
The therapeutic armamentarium has significantly expanded since the approval of various CD19-targeting chimeric antigen receptor T cell (CAR-T)...
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Development of a chromatographic lateral flow immunoassay for detection of African swine fever virus antigen in blood
African swine fever (ASF) is a highly lethal disease of domestic and wild swine caused by African swine fever virus (ASFV). The disease currently...
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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy
Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large...
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Diagnostic performance of MRI in detecting prostate cancer in patients with prostate-specific antigen levels of 4–10 ng/mL: a systematic review and meta-analysis
ObjectiveTo investigate the diagnostic performance of MRI in detecting clinically significant prostate cancer (csPCa) and prostate cancer (PCa) in...
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Evaluation of ECLIA antigen detection tests as screening methods for COVID-19 in comparison with molecular analysis
BackgroundData from literature shows that antigen tests are rapid and helpful tools for diagnosis of COVID-19.
AimThis work aimed to evaluate the...
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Cost-Effectiveness Modeling of Prostate-Specific Membrane Antigen Positron Emission Tomography with Piflufolastat F 18 for the Initial Diagnosis of Patients with Prostate Cancer in the United States
Background and objectivesPiflufolastat F 18 is a novel prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET)...
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Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen: Comparison of Surveillance Strategies Among Patients Who Underwent Resection of Colorectal Cancer—A Systematic Review and Meta-analysis
BackgroundAlmost one-third of colorectal cancer (CRC) patients experience recurrence after resection; nevertheless, follow-up strategies remain...
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Trophoblast Cell Surface Antigen 2 gene (TACSTD2) expression in primary breast cancer
PurposeTrophoblast Cell Surface Antigen 2 (TROP2) is a glycoprotein expressed in many cancers. A TROP2 antibody–drug conjugate (ADC) was effective in...
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Immunization with anti-Tn immunogen in maternal rats protects against hyperoxia-induced kidney injury in newborn offspring
BackgroundNeonatal hyperoxia increases oxidative stress and adversely disturbs glomerular and tubular maturity. Maternal Tn immunization induces...
