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Controlling time-varying confounding in difference-in-differences studies using the time-varying treatments framework
This article clarifies how the biostatistical literature on time-varying treatments (TVT) can provide tools for dealing with time-varying confounding...
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Estimation and inference for the mediation effect in a time-varying mediation model
BackgroundTraditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant...
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The effect of time-varying capacity utilization on 14-day in-hospital mortality: a retrospective longitudinal study in Swiss general hospitals
BackgroundHigh bed-occupancy (capacity utilization) rates are commonly thought to increase in-hospital mortality; however, little evidence supports a...
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Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany
BackgroundCumulative evidence of dementia risk in patients taking proton pump inhibitors (PPIs) is still inconclusive, probably due to a variety of...
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Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics
Background and objectivesReal-time blood flow variation is crucial for understanding the dynamic development of coronary atherosclerosis. The main...
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Time-Varying Determinants of Changes in E-Cigarette Relative Harm Perception Among US Young Adults
BackgroundCurrent e-cigarette use has increased among young adults in the USA despite a consistent decrease in perceiving e-cigarettes as less...
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Time-varying exposure to anti-osteoporosis drugs and risk of first-time hip fracture: a population wide study within the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS)
SummaryWe investigated the association between bisphosphonate and denosumab use and risk of hip fracture in Norway. These drugs protect against...
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Developmental trajectories of conduct problems and time-varying peer problems: the Bergen child study
BackgroundWhile it is increasingly acknowledged that conduct problems and peer problems often co-occur in development, less is known about the ways...
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Time-varying effect of drunk driving regulations on road traffic mortality in Guangzhou, China: an interrupted time-series analysis
BackgroundChina has introduced a series of stricter policies to criminalize drunk driving and increase penalties since May 2011. However, there is no...
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Association of time-varying sleep duration and cognitive function with mortality in the elderly: a 12-year community-based cohort study
BackgroundSlee** problems and cognitive impairment are common in elders. Baseline sleep duration and cognitive status are predictors of mortality....
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Association between the time-varying arterial carbon dioxide pressure and 28-day mortality in mechanically ventilated patients with acute respiratory distress syndrome
BackgroundRecent studies have shown an association between baseline arterial carbon dioxide pressure (PaCO 2 ) and outcomes in patients with acute...
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Enhancing understanding of healthy aging based on time-varying dependencies among multidimensional health, life satisfaction, and health behaviors of older adults aged 60 years and over
BackgroundHealthy aging is a process of not only achieving good health but also increasing the life satisfaction of older adults aged 60 years and...
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Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization
Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into...
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Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents
Background and ObjectivesMilrinone is an inotrope and vasodilator used for prophylaxis or treatment of low cardiac output syndrome after weaning from...
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Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models
BackgroundIn many applications of instrumental variable (IV) methods, the treatments of interest are intrinsically time-varying and outcomes of...
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Differential health impact of intervention programs for time-varying disease risk: a measles vaccination modeling study
BackgroundDynamic modeling is commonly used to evaluate direct and indirect effects of interventions on infectious disease incidence. The risk of...
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Bias amplification in the g-computation algorithm for time-varying treatments: a case study of industry payments and prescription of opioid products
BackgroundIt is often challenging to determine which variables need to be included in the g-computation algorithm under the time-varying setting....
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Time-varying parameters of glycemic control and glycation in relation to arterial stiffness in patients with type 1 diabetes
BackgroundA substantial proportion of type 1 diabetes (T1D) patients free from known cardiovascular disease (CVD) show premature arterial stiffening,...
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Time-varying effects of FOXA1 on breast cancer prognosis
PurposeResults of previous studies on the associations between Forkhead box A1 (FOXA1) expression in breast cancer tissues and the prognosis varied...
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Time-varying association between body mass index and all-cause mortality in patients with hypertension
BackgroundRelationship between BMI and all-cause mortality in patients with hypertension remains controversial. This study aimed to evaluate the...
