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White Paper on the Value of Time Savings for Patients and Healthcare Providers of Breast Cancer Therapy: The Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Injection as an Example
Health technology assessments and value frameworks are becoming increasingly important for clinical decision-making. Most of these frameworks,...
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25 years of lipid-lowering therapy: secular trends in therapy of coronary patients
Background and aimGuidelines on dyslipidemia and lipid-lowering therapy (LLT) over the years recommend lower low-density lipoprotein cholesterol...
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Magnetic seizure therapy and electroconvulsive therapy increase aperiodic activity
Major depressive disorder (MDD) is a leading cause of disability worldwide. One of the most efficacious treatments for treatment-resistant MDD is...
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Bismuth-Based Therapy: The New Therapy for Obese Patients Undergoing Gastric Bypass Surgery?
AimsOur aim was to assess, in obese patients undergoing Roux-en Y gastric bypass surgery, the bismuth quadruple therapy (BQT) eradication rates at...
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Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial
We determined the associations of follow-up blood pressure (BP) after stroke as a time-dependent covariate with the risk of subsequent ischemic...
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The value of biomarkers in the therapy of CRSwNP with biologicals—a long-term follow-up of dupilumab therapy
PurposeSince its release, Dupilumab has shown great results in treating severe uncontrolled CRSwNP. However, there is a lack of real-world data...
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Impacts of early therapy response, interval to therapy interruption, and cumulative therapy interruption duration on outcome of ibrutinib therapy in relapsed/refractory chronic lymphocytic leukemia
To investigate the impact of early response and treatment interruption on the survival of patients with relapsed/refractory chronic lymphocytic...
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The IDEAL (Insulin therapy DE-intensificAtion with iglarLixi) Randomised Controlled Trial—Study Design and Protocol
IntroductionMultiple daily injection insulin regimen (MDI) represents the most intensive insulin regimen used in the management of people with type 2...
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The efficacy of switching basal–bolus insulin therapy to basal insulin-supported oral therapy with a glinide and an α-glucosidase inhibitor in patients with type 2 diabetes depends on insulin secretory capacity, but not on blood glucose profiles and insulin dosages prior to the switching
AimsWe aimed to identify patients who would benefit from basal insulin-supported oral therapy (BOT) with a glinide and an α-glucosidase inhibitor (a...
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Comparative effect of stenting plus medical therapy vs medical therapy alone on the risk of stroke and death in patients with symptomatic intracranial stenosis: a systematic review and meta-analysis
BackgroundRecently, several randomized controlled trials (RCTs) of stenting plus medical therapy versus medical therapy alone have been successfully...
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Effects of cognitive behavioural therapy and bright light therapy for insomnia in youths with eveningness: study protocol for a randomised controlled trial
BackgroundInsomnia and eveningness are common and often comorbid conditions in youths. While cognitive behavioural therapy for insomnia (CBT-I) has...
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The impact of mindfulness therapy combined with mentalization-based family therapy on suicidal ideation in adolescents with depressive disorder: randomized intervention study
BackgroundAdolescents with depression who engage in non-suicidal self harming behaviors are more likely to adopt negative co** strategies when...
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An updated meta-analysis of optimal medical therapy with or without invasive therapy in patients with stable coronary artery disease
BackgroundThe efficacy of optimal medical therapy (OMT) with or without revascularization therapy in patients with stable coronary artery disease...
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Initial treatment with a single capsule containing half-dose quadruple therapy versus standard-dose dual therapy in hypertensive patients (QUADUAL): statistical analysis plan for a randomized, blinded, crossover trial
BackgroundCombined antihypertensive therapy has obvious advantages over single drug therapy. Hypertension guidelines fully affirm the efficacy of...
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Effectiveness of group arts therapies (art therapy, dance movement therapy and music therapy) compared to group counselling for diagnostically heterogeneous psychiatric community patients: study protocol for a randomised controlled trial in mental health services (the ERA study)
BackgroundArts therapies are widely but inconsistently provided in community mental health. Whilst they are appealing to patients, evidence for their...
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Lapatinib and lapatinib plus trastuzumab therapy versus trastuzumab therapy for HER2 positive breast cancer patients: an updated systematic review and meta-analysis
IntroductionTrastuzumab, as the gold standard for HER2-positive BC treatment, was the first-line HER2 targeted drug. However, some studies reported...
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AML consolidation therapy: timing matters
PurposeInfections due to severe neutropenia are the most common therapy-associated causes of mortality in patients with acute myeloid leukemia (AML)....
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Changing from preserved, to preservative-free cyclosporine 0.1% enhanced triple glaucoma therapy: impact on ocular surface disease—a randomized controlled trial
ObjectiveHalting and reversing glaucoma therapy-related ocular surface disease (GTR-OSD) will improve the success of long-term medical therapy,...
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Gene therapy: principles, challenges and use in clinical practice
IntroductionGene therapy is an emerging topic in medicine. The first products have already been licensed in the European Union for the treatment of...
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Half-dose photodynamic therapy versus 577 nm subthreshold pulse laser therapy in treatment-naive patients with central serous chorioretinopathy
BackgroundTo compare real-life anatomical and functional outcomes of half-dose photodynamic therapy (HD-PDT) and 577 nm subthreshold pulse laser...
