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Extracellular status of thrombospondin-2 in type 2 diabetes mellitus and utility as a biomarker in the determination of early diabetic kidney disease
ObjectiveThrombospondin-2 (TSP-2) is a multifunctional matricellular glycoprotein correlated with glucose homeostasis, insulin sensitivity, and...
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Prospective associations of circulating thrombospondin-2 level with heart failure hospitalization, left ventricular remodeling and diastolic function in type 2 diabetes
BackgroundCirculating thrombospondin-2 (TSP2) levels were associated with the development of heart failure (HF) in recent studies. However, these...
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Thrombospondin-2 as a diagnostic biomarker for distal cholangiocarcinoma and pancreatic ductal adenocarcinoma
PurposeDistal cholangiocarcinoma and pancreatic ductal adenocarcinoma are malignancies with poor prognoses that can be difficult to distinguish...
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Thrombospondin 1 Promotes Endoplasmic Reticulum Stress and Apoptosis in HK-2 Cells by Upregulating ATF6-CHOP
ObjectiveThe goal of this study is to investigate the role and mechanism of endoplasmic reticulum stress and apoptosis regulated by thrombospondin 1...
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Thrombospondin-2 promotes the proliferation and migration of glioma cells and contributes to the progression of glioma
BackgroundGliomas, especially high-grade gliomas, are highly malignant with a poor prognosis. Although existing treatments have improved the survival...
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Effects of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A expression in glomerular basement membranes on treatment response and renal outcome in membranous nephropathy
BackgroundThe aim of this study was to define the clinicopathologic features of phospholipase A 2 receptor (PLA 2 R) and/or thrombospondin type-1...
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Concurrent glomerular PCDH7 deposits in PLA2R-associated membranous nephropathy
The understanding of membranous nephropathy (MN) has undergone impressive advancements in the last 5 years, particularly due to identification of...
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Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer
BackgroundThe TRUSTY study evaluated the efficacy of second-line trifluridine/tipiracil (FTD/TPI) plus bevacizumab in metastatic colorectal cancer...
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Proteomic associations with forced expiratory volume: a Mendelian randomisation study
BackgroundA decline in forced expiratory volume (FEV1) is a hallmark of respiratory diseases that are an important cause of morbidity among the...
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Membranous nephropathy: new pathogenic mechanisms and their clinical implications
Membranous nephropathy (MN) is characterized histomorphologically by the presence of immune deposits in the subepithelial space of the glomerular...
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Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most...
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Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis
Thrombospondin 1 (TSP1) is known for its cell-specific functions in cancer progression, such as proliferation and migration. It contains 22 exons...
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Curcumin Interferes with TGF- β 1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation
ObjectiveTo explore the molecular mechanism by which curcumin affects renal interstitial fibrosis (RIF) progression by regulating ADAM...
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Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer
BackgroundThrombospondin-2 (TSP-2) has been reported as an early diagnostic marker for pancreatic ductal adenocarcinoma (PDAC) in Caucasian...
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Diagnostic utility of serum and urine biomarkers in idiopathic membranous nephropathy: a systematic review and meta-analysis
BackgroundMembranous nephropathy is an autoimmune nephropathy that is one of the most common pathological types of nephrotic syndrome. It is...
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Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles
PurposeMolecular processes in primary osteoblasts were analyzed in response to magnetic and electric field exposure to examine its potential impact...
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Double positivity of anti-β2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody
Although a few antiphospholipid syndrome (APS) occurs with acquired thrombotic thrombocytopenic purpura (TTP), the relationship between...
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Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors
BackgroundPreclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of...
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Association of atrial arrhythmias with thrombospondin-1 in patients with acute myocardial infarction
ObjectivesAtrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial...
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Efficacy of knee-balancing manipulation plus heat-sensitive moxibustion for knee osteoarthritis and its influence on CTX- I, TRACP-5b, ADAMTS-4, and MMP-3
ObjectiveTo observe the efficacy of knee-balancing manipulation plus heat-sensitive moxibustion in treating knee osteoarthritis (KOA) and its impact...