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Real-world NUDT15 genoty** and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
BackgroundThis study evaluated the effectiveness of NUDT15 codon 139 genoty** in optimizing thiopurine treatment for inflammatory bowel disease...
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Feasibility of Reduced Clinical Monitoring in Patients with Inflammatory Bowel Disease Treated with Thiopurine Therapy
BackgroundOutpatient visits and laboratory assessments are routinely scheduled every 3 to 4 months in thiopurine-treated patients with inflammatory...
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Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses two major conditions: Crohn’s...
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Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease
BackgroundThe thiopurine medications are well established in the treatment of inflammatory bowel disease (IBD). There is significant variation in...
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Thiopurine pharmacogenomics and pregnancy in inflammatory bowel disease
The thiopurine drugs azathioprine and 6-mercaptopurine are widely used for the maintenance of clinical remission in steroid-dependent inflammatory...
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TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India
BackgroundPolymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of...
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Thiopurine Monotherapy Is Effective in Maintenance of Mild-Moderate Inflammatory Bowel Disease
BackgroundCrohn's disease (CD) and ulcerative colitis (UC) are complex, inflammatory bowel diseases (IBD) with debilitating complications. While...
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The association between pre-colectomy thiopurine use and risk of neoplasia after ileal pouch anal anastomosis in patients with ulcerative colitis or indeterminate colitis: a propensity score analysis
BackgroundThe risk of neoplasia of the pouch or residual rectum in patients with ulcerative colitis (UC) who undergo total proctocolectomy (TPC) with...
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Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation
Background and AimsPolymorphisms in the nucleotide diphosphate-linked moiety X-type motif 15 ( NUDT15 ) gene are associated with thiopurine-induced...
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Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study
BackgroundIn the recent era of growing availability of biological agents, the role of thiopurines needs to be reassessed with the focus on toxicity.
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Prediction of thiopurine failure in pediatric Crohn’s disease: pediatric IBD Porto group of ESPGHAN
BackgroundMaintaining of remission early in the disease course of Crohn’s disease (CD) is essential and has major impact on the future prognosis....
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Is It Useful to Monitor Thiopurine Metabolites in Pediatric Patients with Crohn’s Disease on Combination Therapy? A Multicenter Prospective Observational Study
BackgroundThe additional value of azathioprine concomitant treatment on infliximab pharmacokinetics in children is not well described yet.
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Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn’s Disease: A Retrospective Study
BackgroundAlthough combining thiopurine with infliximab (IFX) is considered to improve the clinical efficacy of IFX when treating Crohn’s disease...
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Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However,...
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Poor Drug Sustainability in Inflammatory Bowel Disease Patients in Clinical Remission on Thiopurine Monotherapy
BackgroundImmunomodulator monotherapy is an important component in the treatment of inflammatory bowel disease (IBD). However, there is conflicting...
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Evaluation of FTO polymorphism in 6-mercaptopurine related intolerance in children with acute lymphoblastic leukemia
PurposeThiopurine drugs like 6-Mercaptopurine (6MP) are the cornerstone of maintenance therapy in acute lymphoblastic leukemia (ALL). A recently...
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No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study
Purpose6-mercaptopurine(6MP)/methotrexate maintenance therapy is essential to reduce relapse of childhood acute lymphoblastic leukemia (ALL). Common...
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Multicenter, cross-sectional, observational study on Epstein–Barr viral infection status and thiopurine use by age group in patients with inflammatory bowel disease in Japan (EBISU study)
BackgroundThe Epstein–Barr virus (EBV) infection status in patients with inflammatory bowel disease (IBD), particularly those using thiopurines, may...
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