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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages...
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Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated by the inactivation of RB1 ...
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Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets
IgA nephropathy (IgAN) is a genetically complex multifactorial trait. Over the past decade, population-based genome-wide association studies (GWAS)...
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Non-coding RNAs as therapeutic targets and biomarkers in ischaemic heart disease
The adult heart is a complex, multicellular organ that is subjected to a series of regulatory stimuli and circuits and has poor reparative potential....
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Emerging Therapeutic Targets for Portal Hypertension
Purpose of ReviewPortal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have...
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Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Psychedelics, also known as classical hallucinogens, have been investigated for decades due to their potential therapeutic effects in the treatment...
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Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets
Lymphatic vessels, comprising the secondary circulatory system in human body, play a multifaceted role in maintaining homeostasis among various...
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Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of...
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Identification of a Group of Therapeutic Targets and Prognostic Biomarker for Triple Negative Breast Cancer
IntroductionTriple-negative breast cancer (TNBC) is a highly heterogeneous disease. Mining differentially expressed genes of TNBC is helpful to...
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Identification of potential crucial genes and therapeutic targets for epilepsy
BackgroundEpilepsy, a central neurological disorder, has a complex genetic architecture. There is some evidence suggesting that genetic factors play...
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Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...
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TAM family kinases as therapeutic targets at the interface of cancer and immunity
Novel treatment approaches are needed to overcome innate and acquired mechanisms of resistance to current anticancer therapies in cancer cells and...
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Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches
Bullous pemphigoid is one of the most common autoimmune bullous diseases occurring primarily in the elderly. Pathogenic autoantibodies against BP180...
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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent...
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Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases
The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the...
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Emerging Therapeutic Targets for Heart Failure
Purpose of ReviewHeart failure is a global epidemic that affects at least 26 million individuals globally and is becoming more prevalent. Despite...
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Novel Therapeutic Targets in Acute Myeloid Leukemia (AML)
Purpose of ReviewThis review seeks to identify and describe novel genetic and protein targets and their associated therapeutics currently being used...
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The gasdermin family: emerging therapeutic targets in diseases
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This...
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Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions...
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Cancer-triggered systemic disease and therapeutic targets
Cancer provokes systemic diseases through three possible mechanisms: 1) Distal metastasis in multiple tissues and organs, which directly causes...
