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The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma
We aimed to evaluate the relationship between imaging features, therapeutic responses (comparative cross-product and volumetric measurements), and...
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Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The...
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Histopathology images-based deep learning prediction of prognosis and therapeutic response in small cell lung cancer
Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer characterized by rapid tumor growth and early metastasis. Accurate...
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Reclassification of therapeutic response of unresectable hepatocellular carcinoma to anti-angiogenic therapy and immunotherapy using alpha RECIST
ObjectivesTo assess the therapeutic response of HCC to antiangiogenic therapy plus immunotherapy by integrating RECIST 1.1 and alpha-fetoprotein...
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Changes in therapeutic response, ocular manifestations of Graves’ orbitopathy and quality of life during the first year after orbital radiotherapy
PurposeThe aim of our study was to assess the changes in the therapeutic response, ocular manifestations of GO and quality of life during the first...
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Serum uric acid predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope: a pilot study
AbstractSerum uric acid (UA) level has been proven to be related to several cardiovascular and metabolic diseases. In the present study, we examined...
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Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation
The CD39-CD73–adenosinergic pathway converts adenosine triphosphate (ATP) to adenosine for inhibiting anti-tumor immune responses. Therefore,...
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Effect of direct therapeutic ultrasound exposure of ovaries on histopathology, inflammatory response, and oxidative stress in dogs
BackgroundThis research was designed to evaluate the effects of therapeutic ultrasound waves on ovarian germinal tissue and inflammatory cytokines...
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Activation of STING by the novel liposomal TLC388 enhances the therapeutic response to anti-PD-1 antibodies in combination with radiotherapy
Current immune checkpoint inhibiters (ICIs) have contrasting clinical results in poorly immunogenic cancers such as microsatellite-stable colorectal...
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Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response
Despite decades of investigations, the optimal assessment of the “therapeutic response” to early after loading dose of acetylsalicylic acid (ASA)...
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Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia
BackgroundNeuroprotection combined with neuroregeneration may be critical for optimizing functional recovery in neonatal encephalopathy. To...
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Pretreatment Pan-Immune-Inflammation Value (PIV) in Predicting Therapeutic Response and Clinical Outcomes of Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma
PurposeThe pan-immune-inflammation value (PIV), which reflects the balance between the host immune and inflammatory status, is a readily available...
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Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine
BackgroundTraditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as...
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Therapeutic Response After Immunosuppressive Drug Prescription in Non-infectious Uveitis: A Survival Analysis
IntroductionTo identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU).
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Evaluation of 18F-FAPI-04 Imaging in Assessing the Therapeutic Response of Rheumatoid Arthritis
PurposeFibroblast activating protein (FAP) is highly expressed in the synovial tissues of rheumatoid arthritis (RA) patients. The aim of this study...
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Molecular subtypes of lung adenocarcinoma patients for prognosis and therapeutic response prediction with machine learning on 13 programmed cell death patterns
BackgroundLung adenocarcinoma (LUAD) seriously threatens people’s health worldwide. Programmed cell death (PCD) plays a critical role in regulating...
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Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists
AimsThe response to Glucagon-like peptide-1 receptor agonists (GLP-1RAs) is highly varia-ble among patients. Thus, the identification of predictive...
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Disulfidptosis-Related lncRNA for the Establishment of Novel Prognostic Signature and Therapeutic Response Prediction to Endometrial Cancer
Disulfidptosis, a newly discovered cellular death mechanism initiated by disulfide stress, features elevated expression of SLC7A11 and restricted...
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Identification of genomic drivers for the therapeutic response of Cabozantinib in patients with metastatic renal cell carcinoma
PurposeCabozantinib (CAB) as monotherapy or in combination with immune checkpoint inhibitors is used for systemic treatment of metastatic renal cell...