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Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization
BackgroundCurrently, the treatment and prevention of migraine remain highly challenging. Mendelian randomization (MR) has been widely used to explore...
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Ferroptosis-related genes, a novel therapeutic target for focal segmental glomerulosclerosis
Recent studies have suggested that ferroptosis participates in various renal diseases. However, its effect on focal segmental glomerulosclerosis...
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Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations
Pterygium, an ocular surface disorder, manifests as a wing-shaped extension from the corneoscleral limbus onto the cornea, impacting vision and...
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Unravelling driver genes as potential therapeutic targets in ovarian cancer via integrated bioinformatics approach
Target-driven cancer therapy is a notable advancement in precision oncology that has been accompanied by substantial medical accomplishments. Ovarian...
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Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational...
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Identification of potential crucial genes and therapeutic targets for epilepsy
BackgroundEpilepsy, a central neurological disorder, has a complex genetic architecture. There is some evidence suggesting that genetic factors play...
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Identification of hub genes and therapeutic siRNAs to develop novel adjunctive therapy for Duchenne muscular dystrophy
ObjectiveDuchenne muscular dystrophy (DMD) is a devastating X-linked neuromuscular disorder caused by various defects in the dystrophin gene and...
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Comprehensive transcriptomic analysis unveils macrophage-associated genes for establishing an abdominal aortic aneurysm diagnostic model and molecular therapeutic framework
BackgroundAbdominal aortic aneurysm (AAA) is a highly lethal cardiovascular disease. The aim of this research is to identify new biomarkers and...
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Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer
BackgroundGastric cancer is one of the major public health problems worldwide. Circadian rhythm disturbances driven by circadian clock genes play a...
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Comprehensive analysis of co-expressed genes with TDP-43: prognostic and therapeutic potential in lung adenocarcinoma
BackgroundTransactivating DNA-binding protein 43 (TDP-43) is intimately associated with tumorigenesis and progression by regulating mRNA splicing,...
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Risk assessment model based on nucleotide metabolism-related genes highlights SLC27A2 as a potential therapeutic target in breast cancer
PurposeBreast cancer (BC) is the most prevalent malignant tumor worldwide among women, with the highest incidence rate. The mechanisms underlying...
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In silico analysis of differentially expressed-aberrantly methylated genes in breast cancer for prognostic and therapeutic targets
Breast cancer (BC) is the leading cause of death among women across the globe. Abnormal gene expression plays a crucial role in tumour progression,...
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Characterization of tumor microenvironment infiltration and therapeutic responses of cell cycle-related genes’ signature in breast cancer
BackgroundIt is unknown how the cell cycle plays a role in breast cancer (BC). This study aimed to establish a clinically applicable predictive model...
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Integrated bioinformatics analysis for the identification of idiopathic pulmonary fibrosis–related genes and potential therapeutic drugs
ObjectiveThe pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unclear. We sought to identify IPF-related genes that may participate in the...
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The Cannabis sativa genetics and therapeutics relationship network: automatically associating cannabis-related genes to therapeutic properties through chemicals from cannabis literature
BackgroundUnderstanding the genome of Cannabis sativa holds significant scientific value due to the multi-faceted therapeutic nature of the plant....
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Identification of key genes and immune infiltration in osteoarthritis through analysis of zinc metabolism-related genes
BackgroundOsteoarthritis (OA) represents a prominent etiology of considerable pain and disability, and conventional imaging methods lack sensitivity...
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Identification of a Group of Therapeutic Targets and Prognostic Biomarker for Triple Negative Breast Cancer
IntroductionTriple-negative breast cancer (TNBC) is a highly heterogeneous disease. Mining differentially expressed genes of TNBC is helpful to...
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Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer
Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a dismal prognosis, with only modest advances in...
