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Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations
Purpose of ReviewTelomere biology disorders (TBD) encompass several illnesses caused by underlying mutations in telomere maintenance leading to...
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Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) encompass a spectrum of genetic diseases with a common pathogenesis of defects in telomerase...
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Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated...
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Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders
Purpose of the ReviewThis study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with...
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Obesity contributes to telomere shortening in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a multifactorial disorder and obesity occurs in 38% to 88% of these women. Although hyperandrogenism may...
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Clonal Hematopoiesis and Myeloid Neoplasms in the Context of Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) are cancer-predisposing multisystemic diseases that portend a higher risk of transforming into...
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Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated...
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Transient elastography in adult patients with cryptic dyskeratosis congenita reveals subclinical liver fibrosis: a retrospective analysis of the Aachen telomere biology disease registry
BackgroundTelomere biology disorders (TBD) such as dyskeratosis congenita (DKC) lead to progressive multi-organ failure as impaired telomere...
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Association between leukocyte telomere length and COVID-19 severity
BackgroundInter-individual variations in the clinical manifestations of SARS-CoV-2 infection are among the challenging features of COVID-19. The...
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Maternal psychological stress during pregnancy and newborn telomere length: a systematic review and meta-analysis
IntroductionTelomeres protect the ends of chromosomes, and shorter leukocyte telomeres are associated with major group diseases. Maternal...
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The effect of metformin treatment on leukocyte telomere length in patients with polycystic ovary syndrome: a prospective case–control study
PurposeThe study aimed to investigate the effect of metformin treatment on leukocyte telomere length (LTL) and the relationship of LTL with...
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Association between the peripartum maternal and fetal telomere lengths and mitochondrial DNA copy numbers and preeclampsia: a prospective case–control study
PurposeTo explore changes in telomere length (TL) and mitochondrial copy number (mtDNA-CN) in preeclampsia (PE) and to evaluate the combined effect...
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Impact of prenatal tobacco smoking on infant telomere length trajectory and ADHD symptoms at 18 months: a longitudinal cohort study
BackgroundPrenatal maternal tobacco smoking is a predictor of child attention-deficit/hyperactivity disorder (ADHD) and is associated with offspring...
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Telomere length and human hippocampal neurogenesis
Short telomere length is a risk factor for age-related disease, but it is also associated with reduced hippocampal volumes, age-related cognitive...
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Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
BackgroundLung biopsy remains the gold standard in the diagnosis of fibrotic interstitial lung disease (F-ILD), but there is a growing appreciation...
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Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure. The metabolic microenvironment has been...
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Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics
The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment from the Alzheimer’s disease (AD) research community to...
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The Relationship Between Vitamin D and Telomere/Telomerase: A Comprehensive Review
Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic...
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Identification of potential blood biomarkers associated with suicide in major depressive disorder
Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive disorder (MDD) is the most common diagnosis among...
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Genetic substrates of bipolar disorder risk in Latino families
Genetic studies of bipolar disorder (BP) have been conducted in the Latin American population, to date, in several countries, including Mexico, the...