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Toward standardization of tau PET imaging corresponding to various tau PET tracers: a multicenter phantom study
ObjectiveTau positron emission tomography (PET) imaging is a recently developed non-invasive tool that can detect the density and extension of tau...
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Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis
ObjectivesTo evaluate the difference of tau burden between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs) or other...
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Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau
Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to accumulate hyperphosphorylated tau pathology, with the...
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18F-Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy
PurposeHuman post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances...
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Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model
BackgroundMicrotubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD)...
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Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular...
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Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study
PurposeTau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer’s disease (AD), but less is known...
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A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model
PurposeDepositions of tau fibrils are implicated in diverse neurodegenerative disorders, including Alzheimer’s disease, and precise assessments of...
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Tau: a biomarker of Huntington’s disease
Develo** effective treatments for patients with Huntington’s disease (HD)—a neurodegenerative disorder characterized by severe cognitive, motor and...
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Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography
PurposeAbnormal tau accumulation within the brain plays an important role in tauopathies such as Alzheimer’s disease and frontotemporal dementia....
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Tau depletion in human neurons mitigates Aβ-driven toxicity
Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological...
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Head-to-Head Comparison of Tau-PET Radioligands for Imaging TDP-43 in Post-Mortem ALS Brain
PurposeIn vivo detection of transactivation response element DNA binding protein-43 kDa (TDP-43) aggregates through positron emission tomography...
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Serum Tau-A and Tau-C Levels and Their Association with Cognitive Impairment and Dementia Progression in a Memory Clinic Derived Cohort
BackgroundSerum-measured fragments of Tau cleaved by ADAM-10 (Tau-A) and Caspase-3 (Tau-C) have been found linked to change in cognitive function and...
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Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form...
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Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging
Tau pathology of the noradrenergic locus coeruleus (LC) is a hallmark of several age-related neurodegenerative disorders, including Alzheimer’s...
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Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
PurposeWe hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more...
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Alzheimer’s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline
For early detection of Alzheimer’s disease, it is important to find biomarkers with predictive value for disease progression and clinical...
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CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease
Post-mortem staging of Alzheimer’s disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for...
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Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
IntroductionNon-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown...
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Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer’s Continuum
BackgroundPlasma p217+tau has shown high concordance with cerebrospinal fluid (CSF) and positron emission tomography (PET) measures of amyloid-β (Aβ)...
