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Future targets for migraine treatment beyond CGRP
BackgroundMigraine is a disabling and chronic neurovascular headache disorder. Trigeminal vascular activation and release of calcitonin gene-related...
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Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated by the inactivation of RB1 ...
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Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification
Novel agents addressing non-amyloid, non-tau targets in Alzheimer’s Disease (AD) comprise 70% of the AD drug development pipeline of agents currently...
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Novel Therapeutic Targets in Acute Myeloid Leukemia (AML)
Purpose of ReviewThis review seeks to identify and describe novel genetic and protein targets and their associated therapeutics currently being used...
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Dialysis for older adults: why should the targets be different?
The number of patients aged > 75-years treated by dialysis continues to increase, particularly in developed countries. Haemodialysis is a...
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Assessment of Innovative Pharmacological Targets in Schizophrenia
Purpose of reviewSchizophrenia is a disorder with an approximate prevalence of 1% associated with great impairments in daily life functioning and...
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Impact of implementing Dutch versus European guideline risk factor targets in older patients with ischaemic heart disease
BackgroundIn patients with ischaemic heart disease (IHD) aged > 70 years, Dutch and European guidelines recommend different treatment targets:...
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Current concepts and novel targets for antiplatelet therapy
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control of platelet hyper-reactivity has become a cornerstone in...
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages...
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CRISPR–Cas9 potential for identifying novel therapeutic targets in muscle-invasive bladder cancer
Gene editing technologies help identify the genetic perturbations driving tumour initiation, growth, metastasis and resistance to therapeutics. This...
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Achievement of Guideline-Recommended Targets for Secondary Prevention of Cardiovascular Disease in 38 Low-Income and Middle-Income Countries
BackgroundThis study aimed to estimate the prevalence of achieving the secondary prevention targets recommended in the World Health Organization...
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Prioritization of drug targets for thyroid cancer: a multi-omics Mendelian randomization study
ObjectivesRecurrence or tumor metastasis and drug resistance remain the major challenge in the treatment of thyroid cancer. It is needed to identify...
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Global Access to Cardiac Surgery Centers: Distribution, Disparities, and Targets
BackgroundGlobal data on cardiac surgery centers are outdated and survey-based. In 1995, there were 0.7 centers per million population, ranging from...
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Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets
IgA nephropathy (IgAN) is a genetically complex multifactorial trait. Over the past decade, population-based genome-wide association studies (GWAS)...
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Emerging Therapeutic Targets for Portal Hypertension
Purpose of ReviewPortal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have...
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Identification of potential crucial genes and therapeutic targets for epilepsy
BackgroundEpilepsy, a central neurological disorder, has a complex genetic architecture. There is some evidence suggesting that genetic factors play...
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Novel targets for potential therapeutic use in Diabetes mellitus
Future targets are a promising prospect to overcome the limitation of conventional and current approaches by providing secure and effective treatment...
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How to Define and Meet Blood Pressure Targets After Traumatic Brain Injury: A Narrative Review
BackgroundTraumatic brain injury (TBI) poses a significant challenge to healthcare providers, necessitating meticulous management of hemodynamic...
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Potential molecular targets and drugs for basement membranes-related intervertebral disk degeneration through bioinformatics analysis and molecular docking
BackgroundThrough bioinformatics analysis to identify the hub genes of Intervertebral disc degeneration (IVDD) associated with basement membranes...
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Neoantigens: promising targets for cancer therapy
Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines,...
