Search
Search Results
-
Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer
The IGF1 signal pathway is highly activated in some subtype of gastric cancer(GC) that exhibits poor survival and chemotherapy resistance. Although...
-
Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Relapse after chemotherapy and hematopoietic stem cell transplantation leads to adverse prognosis for acute myeloid leukemia (AML) patients. As a...
-
Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases
Vascular diseases are a major threat to human health, characterized by high rates of morbidity, mortality, and disability. VSMC senescence...
-
Targeting cancer stem cells as a strategy for reducing chemotherapy resistance in head and neck cancers
PurposeResistance to chemotherapy and radiotherapy is the primary cause of a poor prognosis in oncological patients. Researchers identified many...
-
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
The biosynthesis of host lipids and/or lipid droplets (LDs) has been studied extensively as a putative therapeutic target in diverse viral...
-
-
Targeting sleep and the circadian system as a novel treatment strategy for Parkinson’s disease
There is a growing appreciation of the wide range of sleep–wake disturbances that occur frequently in Parkinson’s disease. These are known to be...
-
Targeting autophagy as a therapeutic strategy against pancreatic cancer
Macroautophagy (hereafter autophagy) is a catabolic process through which cytosolic components are captured in the autophagosome and degraded in the...
-
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 receptor α (IL-11Rα) as a...
-
Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting adverse effect of anticancer therapy that complicates the lifestyle of many...
-
Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
BackgroundCholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1...
-
Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators
Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme present in almost all vertebrate tissues that catalyzes the degradation of...
-
-
Targeting circulating high mobility group box-1 and histones by extracorporeal blood purification as an immunomodulation strategy against critical illnesses
Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation,...
-
Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs
Metastatic cancer remains incurable as patients eventually loose sensitivity to targeted therapies and chemotherapies, further leading to poor...
-
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense...
-
Tau-targeting therapies for Alzheimer disease: current status and future directions
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is characterized pathologically by amyloid-β (Aβ) plaques and...
-
Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different...
-
Targeting epigenetic regulators to overcome drug resistance in cancers
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions...
-
Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute...
