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CD6-targeted antibody-drug conjugate as a new therapeutic agent for T cell lymphoma
T cell lymphomas (TCL) are heterogeneous, aggressive, and have few available targeted therapeutics. In this study, we determined that CD6, an...
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A multi-institutional study to predict the benefits of DEB-TACE and molecular targeted agent sequential therapy in unresectable hepatocellular carcinoma using a radiological-clinical nomogram
ObjectiveExploring the efficacy of a Radiological-Clinical (Rad-Clinical) model in predicting prognosis of unresectable hepatocellular carcinoma...
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Methylated SEPT9 assay-based liquid biopsy as a biomarker in molecular targeted agent-treated hepatocellular carcinoma
BackgroundThe development of molecular targeted agents (MTAs) has changed the treatment strategy for hepatocellular carcinoma (HCC). However,...
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Gene Mutations and Targeted Therapies of Myeloid Sarcoma
Myeloid sarcoma, a rare malignant tumor characterized by the invasion of extramedullary tissue by immature myeloid cells, commonly occurs...
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Development of chitosan-folate modified PLGA nanoparticles for targeted delivery of diosgenin as an anticancer agent
Diosgenin as a potential phytoconstituent and steroidal saponin manifested significant anticancer agents against various cancers. To enhance its...
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Waldenström Macroglobulinemia: Targeted Agents Taking Center Stage
With the worldwide approval of the oral covalent Bruton tyrosine kinase (BTK) inhibitors ibrutinib and zanubrutinib for treating patients with...
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An economic evaluation of cabazitaxel versus a second androgen receptor-targeted agent (ARTA) for patients with metastatic castration-resistant prostate cancer previously treated with docetaxel and an ARTA: the United States payer perspective
BackgroundCabazitaxel significantly improves clinical outcomes compared with a second androgen receptor-targeted agent (ARTA) in patients with...
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Molecular-targeted therapy for childhood low-grade glial and glioneuronal tumors
Since the discovery of the association between BRAF mutations and fusions in the development of childhood low-grade gliomas and the subsequent...
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Molecular Profiling and Targeted Therapies in Gliomas
Purpose of ReviewMolecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection...
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Targeted therapy in BRAF mutated aggressive papillary craniopharyngioma: a case report and overview of the literature
BackgroundPapillary craniopharyngiomas harbor the BRAF V600E mutation, which paves the way for using BRAF inhibitor molecules to treat tumors...
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How do breast cancer clinical trials approach cardiovascular safety: targeted or generalized?
BackgroundDifferent breast cancer pharmacotherapy agents cause different forms of cardiovascular toxicity. We aim to assess if breast cancer...
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Dual-Targeted Therapy in Pediatric Inflammatory Bowel Disease: A Comprehensive Review
Inflammatory bowel disease (IBD) is a chronic systemic immune-mediated disorder. The disease is triggered and perpetuated by a complex interplay...
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Targeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting
T-cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25–30% of adult ALL. Currently, treatment approaches for adult patients with...
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Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review
Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on histological features. Recent molecular profiling studies have...
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Lessons learned in application driven imaging agent design for image-guided surgery
To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique...
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Development of New CD38 Targeted Peptides for Cancer Imaging
PurposeMultiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emission Tomography (PET)...
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Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery
PurposeNon-specific uptake and retention of molecular targeted agents and heterogeneous tissue optical properties diminish the ability to...
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Targeted Therapies in the Treatment of Uterine Serous Carcinoma
Despite the dismal prognosis of uterine serous carcinoma (USC), recent advances in molecular classification and targeted treatments have demonstrated...
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Targeted therapy for osteosarcoma: a review
BackgroundOsteosarcoma is a common primary malignant tumour of the bone that usually occurs in children and adolescents. It is characterised by...
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Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer
Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it. The...
