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A rare case of nephrotic syndrome and Tangier disease
Rarely, disorders of lipid metabolism cause nephrotic syndrome with progressive kidney disease. Tangier disease is a rare condition belonging to this...
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Comparison of different Pancreatic cancer treatments: a three-year retrospective study in the oncology center of Tangier university hospital, Morocco
BackgroundPancreatic cancer is among the most lethal malignancies, with a 5-year overall survival (OS) of less than 10% for all stages. The present...
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What Causes Premature Coronary Artery Disease?
Purpose of ReviewThis review provides an overview of genetic and non-genetic causes of premature coronary artery disease (pCAD).
Recent Findings ...
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Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
While low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascular risk factor,...
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Trends and Factors Affecting Knowledge of and Stigma and Violence Towards Female Sex Workers in Morocco
BackgroundWe investigate factors affecting HIV knowledge, stigma, and violence among female sex workers (FSW) in Agadir, Rabat, Fes, and Tangier,...
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High-Density Lipoprotein Cholesterol in Atherosclerotic Cardiovascular Disease Risk Assessment: Exploring and Explaining the “U”-Shaped Curve
Purpose of ReviewReview updates for the association of HDL-cholesterol with atherosclerotic cardiovascular disease (ASCVD) and discuss the approach...
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Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Chronic kidney disease (CKD) is a global health problem with rising incidence and prevalence. Among several pathogenetic mechanisms responsible for...
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Association of methylation status of ABCA1/G1 genes with the risk of coronary artery disease
BackgroundATP-binding cassette transporters A1/G1 (ABCA1/G1) is a main regulator of HDL (high-density lipoprotein) formation and reverse cholesterol...
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Consensus clinical management guidelines for acid sphingomyelinase deficiency (Niemann–Pick disease types A, B and A/B)
BackgroundAcid Sphingomyelinase Deficiency (ASMD) is a rare autosomal recessive disorder caused by mutations in the SMPD1 gene. This rarity...
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Exome-based gene panel analysis in a cohort of acute juvenile ischemic stroke patients:relevance of NOTCH3 and GLA variants
BackgroundGenetic variants are considered to have a crucial impact on the occurrence of ischemic stroke. In clinical routine, the diagnostic value of...
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Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established....
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Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report
BackgroundKRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS...
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Preventing Premature Atherosclerotic Disease
Purpose of ReviewCardiovascular disease (CVD) can begin in youth. Prevention is essential to reducing the burden of CVD-related risk factors in...
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Behaviour and therapeutic itinerary of epileptic patients in Marrakech city and surrounding regions in South Morocco
BackgroundEpilepsy is a chronic, universal disorder with various etiologies and prognoses. It is still laden with myths in the majority of the...
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Prevalence and risk factors of canine leishmaniasis in Morocco: a systematic review and meta-analysis
Human visceral leishmaniasis has long been associated with canine leishmaniasis (CL). However, to date, there is no clear information on the status...
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Angeborene Störungen des High-density-Lipoprotein-Stoffwechsels
Both low and very high levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of atherosclerotic cardiovascular disease (ASCVD) and...
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Facial onset sensory and motor neuronopathy (FOSMN syndrome): Cases series and systematic review
ObjectiveTo provide new and comprehensive evidence for diagnosis and management of FOSMN syndrome.
MethodsWe reviewed our database to identify...
