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Tamoxifen Dose De-Escalation: An Effective Strategy for Reducing Adverse Effects?
Tamoxifen, a cornerstone in the adjuvant treatment of estrogen receptor-positive breast cancer, significantly reduces breast cancer recurrence and...
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Evaluation of Cervical Cytology in Women with Breast Cancer on Tamoxifen Therapy
ObjectiveTo study the effect of tamoxifen therapy on cervical cytology.
MethodsA cross-sectional study on 100 women was conducted in Department of...
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Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer
BackgroundOvarian cancer is a malignant tumor of the female reproductive system, and its mortality rate is as high as 70%. Estrogen receptor α...
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Foveal cone loss in tamoxifen maculopathy: a case report
BackgroundTamoxifen is used in low dose concentrations (20–40 mg per day) as a therapy for breast cancer but is known to have ocular side effects. In...
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Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells
PurposeRapid proliferation and nutrition starvation in the tumor microenvironment pose significant challenges to cellular protein homeostasis. The...
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Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells
Breast cancer one of the most common diseases in women, has a high death and morbidity rate. Tamoxifen being very much effective in the...
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Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer
BackgroundWe aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer.
Methods ... -
Adverse effects of tamoxifen treatment on bone mineral density in premenopausal patients with breast cancer: a systematic review and meta-analysis
BackgroundIt is well known that adjuvant tamoxifen treatment for breast cancer in postmenopausal women decreased bone loss. However, the effects of...
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Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice
Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen has been proven to...
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A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart
Tamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing...
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Adherence to adjuvant tamoxifen and associated factors in breast cancer survivors
PurposeAdjuvant endocrine therapy reduces the recurrence and mortality of early hormone receptor-positive breast cancer in both pre- and...
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Monopolar spindle 1 contributes to tamoxifen resistance in breast cancer through phosphorylation of estrogen receptor α
PurposeThe overexpression of mitotic kinase monopolar spindle 1 (Mps1) has been identified in many tumor types, and targeting Mps1 for tumor therapy...
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The impact of tamoxifen treatment on voice parameters in premenopausal women with breast cancer
ObjectiveThe study aims to investigate the estrogen-agonistic effects of tamoxifen on voice parameters in premenopausal women diagnosed with breast...
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GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells
Tamoxifen is a first-line therapeutic drug for oestrogen-receptor positive breast cancer; however, like other therapeutics, its clinical use is...
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Relationship between tamoxifen and cataracts: a nationwide cohort study of women in South Korea
PurposeAlthough prospective randomized clinical trials have reported that the use of prophylactic tamoxifen in patients at a high risk of breast...
