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Access to tablet injectable opioid agonist therapy in rural and smaller urban settings in British Columbia, Canada: a qualitative study
BackgroundRural and smaller urban settings in Canada are disproportionately impacted by the overdose crisis, highlighting the need for novel public...
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Extended-release pharmacotherapy for opioid use disorder (EXPO): protocol for an open-label randomised controlled trial of the effectiveness and cost-effectiveness of injectable buprenorphine versus sublingual tablet buprenorphine and oral liquid methadone
BackgroundSublingual tablet buprenorphine (BUP-SL) and oral liquid methadone (MET) are the daily, standard-of-care (SOC) opioid agonist treatment...
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Opioid agonist treatment (OAT) experiences and release plans among federally incarcerated individuals with opioid use disorder (OUD) in Ontario, Canada: a mixed-methods study
BackgroundIncarcerated populations experience an elevated prevalence of opioid use disorder (OUD). Federal correctional institutions in Canada have...
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A Guide to Expanding the Use of Buprenorphine Beyond Standard Initiations for Opioid Use Disorder
Buprenorphine has become an important medication in the context of the ongoing opioid epidemic. However, complex pharmacologic properties and varying...
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Opioid Use Disorder: Approach to Intrapartum and Postpartum Management
Purpose of ReviewThe care of pregnant people with opioid use disorder (OUD) presents unique challenges that have escalated with the opioid epidemic...
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Smoking identified as preferred mode of opioid safe supply use; investigating correlates of smoking preference through a 2021 cross-sectional study in British Columbia
BackgroundThe increasing number of illicit drug toxicity deaths in British Columbia (BC) has led to calls for a regulated (pharmaceutical grade)...
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Understanding and co-managing medication treatment options for opioid use disorder
The number of patients with opioid use disorder (OUD) has increased dramatically. Substance use disorders in general are thought to occur in one in...
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Patterns of use and adverse events reported among persons who regularly inject buprenorphine: a systematic review
Background and AimsGiven the ongoing opioid crisis, novel interventions to treat severe opioid use disorder (OUD) are urgently needed. Injectable...
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Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review
Purpose of ReviewThe tissue damage and trauma associated with surgery almost always result in acute postoperative pain. The intensity of...
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Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs
BackgroundMedications for opioid use disorder (MOUD; methadone, buprenorphine, naltrexone) are the most effective treatments for OUD, and MOUD is...
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High-dose intravenous hydromorphone for patients who use opioids in the hospital setting: time to reduce the barriers
Individuals who use opioids have higher rates of hospitalization compared to the general population. Insufficiently treated withdrawal and pain are...
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Current and Future Therapeutic Options in Pain Management: Multi-mechanistic Opioids Involving Both MOR and NOP Receptor Activation
Opioids are widely used in chronic pain management, despite major concerns about their risk of adverse events, particularly abuse, misuse, and...
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Emerging Viral and Bacterial Infections: Within an Era of Opioid Epidemic
The opioid epidemic is a public health crisis that continues to impact healthcare in the United States of America (USA). While changes in opioid...
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“I have such a hard time hitting myself, I thought it’d be easier”: perspectives of hospitalized patients on injecting drugs into vascular access devices
BackgroundHospital patients who use drugs may require prolonged parenteral antimicrobial therapy administered through a vascular access device (VAD)....
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Observational Analysis of the Costs Associated with Acute Treatment of Breakthrough Migraine Attacks in Medicaid Patients Using Preventive Therapies
IntroductionMedications for preventive treatment of migraine reduce migraine frequency, usually measured by a reduction in monthly migraine days...
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Community partner perspectives on the implementation of a novel safer supply program in Canada: a qualitative study of the MySafe Project
BackgroundThe adulteration of the illicit drug supply with fentanyl and its analogues is driving the ongoing overdose crisis in North America. While...
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Update on Pediatric Anti-obesity Medications—Current Landscape and Approach to Prescribing
Purpose of ReviewTo review the current medical therapies available for treatment of obesity in children and adolescents less than 18 years old in the...
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New Approaches in Drug Dependence: Opioids
Purpose of ReviewThis article aims to provide an overview of standard and adjunctive treatment options in opioid dependence in consideration of...
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Impact of safer supply programs on injection practices: client and provider experiences in Ontario, Canada
ObjectivesFentanyl has contributed to a sharp rise in the toxicity of the unregulated drug supply and fatal overdoses in Canada. It has also changed...