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Association of TGFB -509C>T promoter polymorphism with primary angle closure glaucoma in a North Indian Punjabi cohort
PurposeTransforming growth factor beta (TGFB) is an important candidate gene implicated in glaucoma pathogenesis because it affects retinal...
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ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer
Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or...
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The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
BackgroundThe S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological...
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TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model
BackgroundIntervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF)...
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Increasing transforming growth factor-beta concentrations with age decrease apelin in the rat rotator cuff
BackgroundThe rotator cuff undergoes natural degeneration with age, leading to age-related rotator cuff tear; however, the precise mechanism remains...
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Expression deregulation of matrix metalloproteinases and vasoconstriction related genes in Pakistani females with abnormal uterine bleeding
BackgroundAbnormal uterine bleeding (AUB) is irregular menstrual bleeding which has great impact on female health and life style. Various genetic...
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Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension
Resistant hypertension (RH) poses a significant health challenge, yet its underlying pathogenesis remains unclear. This study employs untargeted...
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Treatment of Anemia in Lower-Risk Myelodysplastic Syndrome
A majority of patients with lower-risk myelodysplastic syndrome (MDS) will present with or develop anemia. Anemia in MDS is associated with decreased...
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Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells
AimObesity is linked to cardiometabolic diseases, however non-obese individuals are also at risk for type 2 diabetes (T2D) and cardiovascular disease...
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The extracts of osteoblast developed from adipose-derived stem cell and its role in osteogenesis
Cell-based therapy has become an achievable choice in regenerative medicines, particularly for musculoskeletal disorders. Adipose-derived stem cells...
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Porcine reproductive and respiratory virus 2 infection of the fetus results in multi-organ cell cycle suppression
Porcine reproductive and respiratory syndrome virus (PRRSV) infection during late gestation negatively affects fetal development. The objective of...
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Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1
Background and purposeMyotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy and is caused by an repeat expansion...
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Differential Regulation of Immune-Related Genes in the Develo** Heart
In many congenital heart defects, it can be difficult to ascertain primary pathology from secondary consequences from altered flow through the...
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Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
BackgroundChronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical...
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CACNA2D1 regulates the progression and influences the microenvironment of colon cancer
BackgroundCalcium voltage-gated channel auxiliary subunit alpha 2/delta 1 ( CACNA2D1 ), a gene encoding a voltage-gated calcium channel, has been...
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Aseptic loosening around total joint replacement in humans is regulated by miR-1246 and miR-6089 via the Wnt signalling pathway
BackgroundTotal joint replacement for osteoarthritis is one of the most successful surgical procedures in modern medicine. However, aseptic loosening...
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Role of transforming growth factor beta in assessment of severity of hypersensitivity pneumonitis: a single center study
BackgroundHypersensitivity pneumonitis (HP) is a more frequently diagnosed picture of diffuse parenchymal lung disease. It is an inflammation of the...
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Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft-tissue malignancy with a poor overall survival and no effective therapeutic...
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Distinguishing features of depression in dementia from primary psychiatric disease
Depression is a common and devastating neuropsychiatric symptom in the elderly and in patients with dementia. In particular, nearly 80% of patients...
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The evaluation of six genes combined value in glioma diagnosis and prognosis
PurposeGlioma is the most common and fatal type of brain tumour. Owing to its aggressiveness and lethality, early diagnosis and prediction of patient...
