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From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications
The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under...
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Tn3-like structures co-harboring of blaCTX-M-65, blaTEM-1 and blaOXA-10 in the plasmids of two Escherichia coli ST1508 strains originating from dairy cattle in China
The purpose of this study was to determine the level of horizontal transmission of the bla CTX-M-65 gene and the role of its associated mobile genetic...
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177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma
PurposeTEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and...
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Molecular characterization of blaNDM, blaOXA-48, mcr-1 and blaTEM-52 positive and concurrently carbapenem and colistin resistant and extended spectrum beta-lactamase producing Escherichia coli in chicken in Malaysia
BackgroundAntimicrobial resistance (AMR) is a global public health threat and the use of antibiotics growth promoters in food animals has been...
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Comparing advanced platforms for local excision of rectal lesions
BackgroundTransanal surgery facilitates organ preservation in select patients with benign and early malignant rectal lesions to avoid the functional...
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Mobile phone applications for 3-dimensional scanning and digital anthropometry: a precision comparison with traditional scanners
BackgroundThe precision of digital anthropometry through 3-dimensional (3D) scanning has been established for relatively large, expensive,...
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Transanal endoscopic microsurgery technique: an acceptable approach for retrorectal tumors
IntroductionRetrorectal lesions (RRLs) are rare lesions that originate from the tissue present in the retrorectal space. The gold standard of care is...
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Transmission electron microscopic study of the surface layer of surgical resected disc specimens in human temporomandibular joint
In this study, we investigated specific and characteristic findings of the surface layer of surgical resected disc specimens in human...
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A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma
PurposeThe optimal duration of post-radiation temozolomide in newly diagnosed glioblastoma remains unclear, with no published phase III randomised...
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Establishment of a promising vitiligo mouse model for pathogenesis and treatment studies
AimsVitiligo is a chronic dermatological condition characterized by the progressive loss of melanocytes, for which traditional therapy has shown...
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Safety of YAG laser vitreolysis for intraocular tissues: analysis of postoperative complications
PurposeTo evaluate the safety of yttrium–aluminum-garnet (YAG) laser vitreolysis for intraocular tissues.
MethodsThirty-six New Zealand rabbits were...
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Hygiene practices and antibiotic resistance among dental and medical students: a comparative study
PurposeHealthcare students' hand and smartphone hygiene is critical due to potential pathogenic and antibiotic-resistant bacteria transmission. This...
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Comparison of advanced techniques for local excision of rectal lesions: a case series
BackgroundRobotic transanal minimally invasive surgery (R-TAMIS) is an appealing alternative to transanal minimally invasive surgery (TAMIS) and...
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Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors
BackgroundTransanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the...
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Autophagy-prominent cell clusters among human lens epithelial cells: integrated single-cell RNA-sequencing analysis
BackgroundAutophagy is an important process that maintains the quality of intracellular proteins and organelles. There is extensive evidence that...
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Defunctioning stoma and anastomotic stricture in rectal cancer surgery: a propensity score matching study
BackgroundIn cases of rectal cancer surgery, patients at high risk of anastomotic leakage often receive a defunctioning stoma (DS). However, its role...
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Short-term clinical and functional results of rectal wall suture defect after transanal endoscopic microsurgery—a prospective cohort study
PurposeOur goal was to assess the outcomes of rectal wall suture during the early and late periods after transanal endoscopic microsurgery (TEM) and...
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Effect of doramectin on programmed cell death pathway in glioma cells
PurposeDoramectin (DRM) is a kind of avermectin drugs, and it has been shown that DRM has anti-cancer effects. However, the molecular mechanism of...
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Biogenic zinc selenide nanoparticles fabricated using Rosmarinus officinalis leaf extract with potential biological activity
Zinc selenide nanoparticles (ZnSe) are semiconductor metals of zinc and selenium. ZnSe NPs are advantageous for biomedical and bio-imaging...
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Results of thermal osteonecrosis for implant removal on electron microscopy, implant stability, and radiographic parameters – a rat study
BackgroundThis rat study aimed to evaluate the feasibility of temperature thresholds that affect peri-implant bone cells and morphology and the...
