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1. In-target production of [¹¹C]CH₄ from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature

   Background

   Production of [ ¹¹ C]CH ₄ from gas targets is notorious for weak performance with respect to yield, especially when using high beam currents....

   Semi Helin, Johan Rajander, ... Olof Solin in EJNMMI Radiopharmacy and Chemistry

   Article Open access 25 March 2024
   

2. Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis

   Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic synovitis and bone destruction. Proinflammatory cytokines activate...

   Fen Zhang, Ting Cheng, Sheng-**ao Zhang in Arthritis Research & Therapy

   Article Open access 02 October 2023
   

3. Multi-target field control for matrix gradient coils

   Objective

   Conventional single-target field control for matrix gradient coils will add control complexity in MRI spatial encoding, such as designing...

   Hongyan He, Shufeng Wei, ... Wenhui Yang in Magnetic Resonance Materials in Physics, Biology and Medicine

   Article 22 February 2024
   

4. Treat-to-Target in Atopic Dermatitis

   Atopic dermatitis is one of the most common inflammatory skin diseases among children and adults. Over the last 5 years, the armamentarium for the...

   Christian Vestergaard, Catalina Skovsgaard, ... Jacob P. Thyssen in American Journal of Clinical Dermatology

   Article 11 December 2023
   

5. Claudin 18.2 as a novel therapeutic target

   Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant gastric epithelium, becomes accessible on the tumour cell surface...

   Izuma Nakayama, Changsong Qi, ... Kohei Shitara in Nature Reviews Clinical Oncology

   Article 19 March 2024
   

6. Atypical pituitary hormone-target tissue axis

   A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions....

   Chao Xu, Zhao He, ... Jiajun Zhao in Frontiers of Medicine

   Article 27 February 2023

7. Designing combinational herbal drugs based on target space analysis

   Background

   Traditional oriental medicines (TOMs) are a medical practice that follows different philosophies to pharmaceutical drugs and they have been...

   Assefa Mussa Woyessa, Lemessa Etana Bultum, Doheon Lee in BMC Complementary Medicine and Therapies

   Article Open access 01 May 2024
   

8. Baseline Target Moderation and Baseline Target Moderation Mediation Approaches: Reflections on Cultural Adaptation and Social Justice

   Baseline target moderation (BTM) and baseline target moderated mediation (BTMM) constitute critical methodological and analytical approaches for the...

   Rubén Parra-Cardona in Prevention Science

   Article 24 October 2022

9. Efficacy and safety of multi-target therapy in children with lupus nephritis

   Background

   To analyze the efficacy and safety of multi-target therapy in children with lupus nephritis (LN).

   Methods

   In our retrospective study from...

   **aohong Zheng, **aojun Ouyang, ... **aoyun Jiang in Pediatric Research

   Article 24 July 2023
   

10. Emulating a Target Trial in Perinatal Pharmacoepidemiology: Challenges and Methodological Approaches

    Purpose of Review

    The objective of this review is to examine the application of target trial emulation in perinatal pharmacoepidemiology research....

    Sabrina Chiodo, Lauren Tailor, ... Sonia M. Grandi in Current Epidemiology Reports

    Article 21 November 2023
    

11. The optimal glycemic target in critically ill patients: an updated network meta-analysis

    Acute glycemic control significantly affects the clinical outcomes of critically ill patients. This updated network meta-analysis examines the...

    Aiko Tanaka, Tomoaki Yatabe, ... Moritoki Egi in Journal of Intensive Care

    Article Open access 14 April 2024

12. HDL as a Treatment Target: Should We Abandon This Idea?

    Purpose of Review

    High-density lipoproteins (HDL) have long been regarded as an antiatherogenic lipoprotein species by virtue of their role in reverse...

    Floran Begue, Marie Laurine Apalama, ... Olivier Meilhac in Current Atherosclerosis Reports

    Article 05 December 2023
    

13. CaMKK2 as an emerging treatment target for bipolar disorder

    Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy,...

    Jacqueline Kaiser, Kevin Nay, ... John W. Scott in Molecular Psychiatry

    Article Open access 20 September 2023
    

14. Treat-to-Target in Pediatric Rheumatic Diseases

    Purpose of Review

    To summarize the current evidence on the adoption of the treat-to-target (T2T) strategy in pediatric rheumatic diseases (PRD).

    ...

    Silvia Rosina, Ana Isabel Rebollo-Giménez, ... Angelo Ravelli in Current Rheumatology Reports

    Article 16 August 2023
    

15. Comparing conventional treatment, single-target rTMS, or dual-target rTMS for the treatment of post-stroke cognitive impairment — clinical effects and neuroscientific insights: study protocol for a randomized controlled trial

    Background

    Although increasing evidence suggests that repetitive transcranial magnetic stimulation may help improve cognitive impairment after stroke,...

    Bingshan Xu, Chunrong Lin, ... Hong Wang in Trials

    Article Open access 27 July 2023
    

16. SRPKs: a promising therapeutic target in cancer

    Cancers such as lung, breast, colon, and prostate have been linked to dysregulation of SRPKs. In preclinical studies, inhibition of SRPKs has been...

    Muhammad Tufail, Changxin Wu in Clinical and Experimental Medicine

    Article 07 April 2023
    

17. Delineation of clinical target volume in nasopharyngeal carcinoma

    Radiotherapy is the mainstay treatment modality for nasopharyngeal carcinoma (NPC). Intensity-modulated radiation therapy (IMRT), as the standard...

    Quxia Zhang, Shaohui Huang, Shaojun Lin in Holistic Integrative Oncology

    Article Open access 12 July 2023

18. HER3 (ERBB3) amplification in liposarcoma - a putative new therapeutic target?

    Background

    Liposarcomas are among the most common mesenchymal malignancies. However, the therapeutic options are still very limited and so far,...

    Ann-Katharina Becker, Behrus Puladi, ... Till Braunschweig in World Journal of Surgical Oncology

    Article Open access 17 May 2024
    

19. PAQR4 oncogene: a novel target for cancer therapy

    Despite decades of basic and clinical research and trials of promising new therapies, cancer remains a major cause of morbidity and mortality due to...

    Dipti Patil, Swapnil Raut, ... Lokesh Kumar Bhatt in Medical Oncology

    Article 20 May 2024
    

20. Target and non-target vessel related events at 10 years post percutaneous coronary intervention

    Aims

    To define the incidence of events related to the stented vessel (target vessel related events: TVRE) and events related to non-stented vessels...

    J. J. Coughlan, Alp Aytekin, ... Sebastian Kufner in Clinical Research in Cardiology

    Article Open access 11 February 2022